{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:53:53Z","timestamp":1747184033735,"version":"3.40.5"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T00:00:00Z","timestamp":1610928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Current UK referral criteria stipulate that hoarseness should be persistent to merit 2\u00a0week wait (2WW) or urgent suspicion of cancer (USOC) referral. This study delineates patterns of hoarseness presentation with a view to assisting referral pathways, and whereby reassurance could be provided.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A pre\u2010existing database of patients referred with hoarseness under the urgent suspicion of cancer (USOC) category was analysed. Univariate and multivariate analyses were performed on a variety of demographic and comorbid features to produce odds ratios (OR) of features either related or not related to laryngeal cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 698 consecutive hoarseness referrals were studied. In these referrals there were 506(73%) with persistent hoarseness and 192(27%) with intermittent hoarseness. The most significant patient variables related to laryngeal cancer were persistent hoarseness (OR 4.97), recreational drug use (OR 4.94), male gender (OR 4.01) and weight loss (OR 3.75). Significant patient variables present not related to laryngeal cancer diagnosis were intermittent hoarseness (OR 0.2), the presence of cough (OR 0.2), globus sensation (OR 0.25) and recent viral infection (OR 0.29).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The strongest association with cancer is seen in patients that are persistently hoarse. Patients with fluctuating hoarseness do not need an \u201curgent suspicion of cancer\u201d referral. Additional demographic referral information could help to streamline the referral of these patients, and reassure others.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.13712","type":"journal-article","created":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T19:27:11Z","timestamp":1610047631000},"page":"562-569","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Patterns of urgent hoarseness referrals to ENT\u2014When should we be suspicious of cancer?"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5564-1513","authenticated-orcid":false,"given":"Catriona M","family":"Douglas","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Queen Elizabeth University Hospital Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Crawford","family":"Middleton","sequence":"additional","affiliation":[{"name":"Department of Mathematics &amp; Statistics University of Strathclyde Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pauline","family":"Sim","sequence":"additional","affiliation":[{"name":"University of Glasgow Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan","family":"Wight","sequence":"additional","affiliation":[{"name":"University of Glasgow Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Mathematics &amp; Statistics University of Strathclyde Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth","family":"MacKenzie","sequence":"additional","affiliation":[{"name":"School of Psychological Studies and Health Strathclyde University Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5000-4913","authenticated-orcid":false,"given":"Jenny","family":"Montgomery","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Queen Elizabeth University Hospital Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,1,18]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"Head and neck cancers \u2010 recognition and referral \u2010 NICE CKS. 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National Institute for Health and Care Excellence (UK); 2016.Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26913319."},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215118000282"},{"key":"e_1_2_11_10_1","unstructured":"statistics.gov.scot:Scottish Index of Multiple Deprivation [Internet]. [Cited 2019 Apr 16]. Available from: https:\/\/statistics.gov.scot\/data\/scottish\u2010index\u2010of\u2010multiple\u2010deprivation\u20102016."},{"key":"e_1_2_11_11_1","unstructured":"Is my study research? [Internet]. [cited 2019 Apr 16]. Available from: http:\/\/www.hra\u2010decisiontools.org.uk\/research\/."},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3399\/bjgp19X700997"},{"key":"e_1_2_11_13_1","unstructured":"Head and Neck Cancers [Internet]. [Cited 2019 Jun 5]. 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