{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:55:08Z","timestamp":1790283308719,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T00:00:00Z","timestamp":1612915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100013945","name":"Institut de Recherches Servier","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013945","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the evolution of symptoms and findings of laryngopharyngeal reflux (LPR) patients according to the type of reflux (acid, non\u2010acid, mixed and gastro\u2010oesophageal (GERD)).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective uncontrolled multicentre study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred and six patients with LPR have been recruited from 3 European Hospitals. According to the reflux characteristics at the impedance\u2010pH monitoring (acid, non\u2010acid, mixed, GERD), patients received a personalised treatment based on the association of diet, pantoprazole, alginate or magaldrate for 3\u00a0months. Reflux Symptom Score (RSS) was assessed at baseline, 6 and 12\u00a0weeks post\u2010treatment. Reflux Sign Assessment (RSA) has been used to rate laryngeal and extra\u2010laryngeal findings at baseline and 12\u00a0weeks post\u2010treatment. Overall success rate and the evolution of symptoms and findings were evaluated according to the LPR types.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and two LPR patients (42 acid, 33 non\u2010acid, 27 mixed, including 49 with LPR and GERD) completed the study. RSS and RSA total scores significantly improved from baseline to post\u2010treatment time in acid, mixed and non\u2010acid groups. The presence of GERD in addition to LPR did not impact the clinical improvement. The 3\u2010month success rates of treatment ranged from 62% to 64%, and there were no significant differences between groups. The success rate of patients with non\u2010acid LPR was similar to those of patients with mixed and acid LPR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>MII\u2010pH is useful to specify the type of LPR and the related most adequate therapeutic regimen. Non\u2010acid or mixed LPR similarly respond to treatment than acid LPR but require a treatment based on alginate or magaldrate covering the non\u2010acid proximal reflux events.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.13722","type":"journal-article","created":{"date-parts":[[2021,1,27]],"date-time":"2021-01-27T17:53:34Z","timestamp":1611770014000},"page":"602-613","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["The efficacy of a personalised treatment depending on the characteristics of reflux at multichannel intraluminal impedance\u2010pH monitoring in patients with acid, non\u2010acid and mixed laryngopharyngeal reflux"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0845-0845","authenticated-orcid":false,"given":"J\u00e9r\u00f4me R.","family":"Lechien","sequence":"first","affiliation":[{"name":"Laryngopharyngeal Reflux Study Group of Young\u2010Otolaryngologists of the International Federations of Oto\u2010rhino\u2010laryngological Societies (YO\u2010IFOS) Paris France"},{"name":"Laboratory of Anatomy and Cell Biology Faculty of Medicine UMONS Research Institute for Health Sciences and Technology University of Mons (UMons) Mons Belgium"},{"name":"Laboratory of Phonetics Faculty of Psychology Research Institute for Language sciences and Technology University of Mons (UMons) Mons Belgium"},{"name":"Department of Otorhinolaryngology and Head and Neck Surgery CHU Saint\u2010Pierre Universit\u00e9 Libre de Bruxelles Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francois","family":"Bobin","sequence":"additional","affiliation":[{"name":"Laryngopharyngeal Reflux Study Group of Young\u2010Otolaryngologists of the International Federations of Oto\u2010rhino\u2010laryngological Societies (YO\u2010IFOS) Paris France"},{"name":"Department of Otorhinolaryngology and Head and Neck Surgery Polyclinique de Poitiers Poitiers 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of the International Federations of Oto\u2010rhino\u2010laryngological Societies (YO\u2010IFOS) Paris France"},{"name":"Department of Otorhinolaryngology and Head and Neck Surgery CHU Saint\u2010Pierre Universit\u00e9 Libre de Bruxelles Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihaela","family":"Horoi","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery CHU Saint\u2010Pierre Universit\u00e9 Libre de Bruxelles Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Paule","family":"Thill","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery CHU Saint\u2010Pierre Universit\u00e9 Libre de Bruxelles Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Rodriguez Ruiz","sequence":"additional","affiliation":[{"name":"Laryngopharyngeal Reflux Study Group of 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