{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:39:29Z","timestamp":1787161169124,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,2,15]],"date-time":"2021-02-15T00:00:00Z","timestamp":1613347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>(a) To report the xerostomia prevalence and severity in patients with obstructive sleep apnoea (OSA). (b) To assess the saliva pH in patients with OSA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Simultaneous cohort observational clinical study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>In Sleep Medicine Centre at Lomonosov Moscow State University from March to June 2019.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>The study was conducted on 30 patients with OSA aged from 35 to 65\u00a0years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main outcomes measures<\/jats:title>\n                    <jats:p>The diagnosis of sleep apnoea was made after standard polysomnography using the Domino programme. The severity of OSA was indicated using the Apnoea\u2010Hypopnea Index. Xerostomia was evaluated using Fox's test. Hyposalivation was evaluated by measurement of salivary flow rate. Determination of the saliva pH was carried out with a pH metre. Statistical analysis was performed by one\u2010way ANOVA and Tukey\u2010Kramer multi\u2010comparison test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty\u2010two out of 30 (73.3%) patients were diagnosed with \"dry mouth\". Hyposalivation was observed in 6 out of 30 (20%). Dry mouth on awakening was observed in 60.0%, 72.7% and 88.9% of patients with mild, moderate and severe OSA, respectively. The average salivary flow rate was 0.28\u00a0mL\/min, 0.24\u00a0mL\/min and 0.14\u00a0mL\/min, respectively. The average pH value in patients with mild, moderate and severe apnoea was 6.40\u00a0\u00b1\u00a00.017, 6.15\u00a0\u00b1\u00a00.27 and 5.87\u00a0\u00b1\u00a00.24, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      In patient with mild and moderate OSA, the saliva amount and rate are similar (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&gt;\u00a0.05). With the increase of OSA severity, both these parameters change (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001). The acidity of the saliva was correlated with the level of OSA, and it statistically increased with the increment of the OSA severity (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.05\u2010\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/coa.13735","type":"journal-article","created":{"date-parts":[[2021,2,6]],"date-time":"2021-02-06T10:26:32Z","timestamp":1612607192000},"page":"782-787","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Xerostomia and hyposalivation in patients with obstructive sleep apnoea"],"prefix":"10.1111","volume":"46","author":[{"given":"Irina Michajlovna","family":"Makeeva","sequence":"first","affiliation":[{"name":"Department of Therapeutic Dentistry Institute of Dentistry I. M. Sechenov First Moscow State Medical University Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana Vasilievna","family":"Budina","sequence":"additional","affiliation":[{"name":"Department of Therapeutic Dentistry Institute of Dentistry I. M. Sechenov First Moscow State Medical University Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Yurjevna","family":"Turkina","sequence":"additional","affiliation":[{"name":"Department of Therapeutic Dentistry Institute of Dentistry I. M. Sechenov First Moscow State Medical University Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikhail Gurevich","family":"Poluektov","sequence":"additional","affiliation":[{"name":"Department of Neurology I. M. Sechenov First Moscow State Medical University Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey Alexeevitch","family":"Kondratiev","sequence":"additional","affiliation":[{"name":"Department of Therapeutic Dentistry Institute of Dentistry I. M. Sechenov First Moscow State Medical University Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna Georgievna","family":"Arakelyan","sequence":"additional","affiliation":[{"name":"Department of Therapeutic Dentistry Institute of Dentistry I. M. Sechenov First Moscow State Medical University Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Signore","sequence":"additional","affiliation":[{"name":"Department of Therapeutic Dentistry Institute of Dentistry I. M. Sechenov First Moscow State Medical University Moscow Russia"},{"name":"Department of Surgical and Diagnostic Sciences (D.I.S.C) University of Genoa Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0494-7942","authenticated-orcid":false,"given":"Andrea","family":"Amaroli","sequence":"additional","affiliation":[{"name":"Department of Surgical and Diagnostic Sciences (D.I.S.C) University of Genoa Genoa Italy"},{"name":"Department of Orthopedic Dentistry Institute of Dentistry I. M. 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