{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T03:14:39Z","timestamp":1787800479212,"version":"build-2784847793"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T00:00:00Z","timestamp":1621814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To study the profile of patients with obstructive sleep apnoea syndrome (OSAS) and laryngopharyngeal reflux (LPR) at the hypopharyngeal\u2010oesophageal multichannel intraluminal impedance\u2010pH monitoring (HEMII\u2010pH) and to compare their reflux findings with LPR patients without OSAS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective controlled study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with LPR and OSAS were prospectively recruited from August 2019 to June 2020. The profile of hypopharyngeal reflux events (HREs) of patients was studied through a breakdown of the HEMII\u2010pH findings over the 24\u00a0hours of testing. Reflux symptom score (RSS), and gastrointestinal and HEMII\u2010pH outcomes were compared between LPR patients and patients with LPR and OSAS. Multivariate analysis was used to study the relationship between reflux data and the following sleep outcomes: Apnea Hypopnea Index, Epworth Sleepiness Scale (ESS) and paradoxical sleep data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 89 patients completed the study. There were 45 patients with LPR and 44 subjects with both OSAS and LPR. The numbers of upright and daytime HREs and the otolaryngological RSS were significantly higher in patients with LPR compared with those with OSAS and LPR. There was a significant positive association between RSS quality\u2010of\u2010life score and ESS (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.001). The occurrence of HREs in the evening was associated with higher ESS (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.015). Patients with OSAS, LPR and GERD had higher number of nocturnal HREs compared with those without GERD (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The presence of OSAS in LPR patients is associated with less severe HEMII\u2010pH and ear, nose and throat symptoms. There may have different OSAS patient profiles according to the occurrence of GERD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.13745","type":"journal-article","created":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T20:54:30Z","timestamp":1614113670000},"page":"816-822","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Impedance\u2010pH monitoring profile of patients with reflux and obstructive sleep apnea syndrome: A controlled study"],"prefix":"10.1111","volume":"46","author":[{"given":"Francois","family":"Bobin","sequence":"first","affiliation":[{"name":"Laryngopharyngeal Reflux Study Group of Young\u2010Otolaryngologists of the International Federations of Oto\u2010rhino\u2010laryngological Societies (YO\u2010IFOS) Paris France"},{"name":"Polyclinique Elsan de Poitiers Poitiers 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