{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T03:08:12Z","timestamp":1790996892330,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T00:00:00Z","timestamp":1619481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Sialocele and salivary fistula are not serious but troublesome complications after parotidectomy. Various modalities have been introduced to prevent postoperative saliva\u2010related complications. However, clinical trials assessing the prophylactic use of botulinum toxin (BTX) for parotidectomy have not been conducted yet. Herein, we report a pilot study investigating the safety and efficacy of intraoperative BTX (iBTX) injection in partial superficial parotidectomy (PSP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Patients with benign parotid tumour were prospectively recruited for this clinical trial from 2017 to 2019. The study participants underwent PSP with iBTX injection. We retrospectively reviewed the clinical information of all the consecutive patients who underwent PSP without iBTX from 2013 to 2019. These patients were divided into two groups: the iBTX group (n\u00a0=\u00a036) and the control group (n\u00a0=\u00a054).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Permanent facial palsy was not observed in either group. Two patients (3.7%) had transient marginal palsy in the control group but none had it in the iBTX group. The incidence of sialocele was significantly lower in the iBTX group than in the control group (2.8% vs. 20.4%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.05). Although the incidence of salivary fistula was lower in the iBTX group than in the control group (0% vs. 7.4%), no significant difference was determined between the two groups (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.147). Total drainage volume was significantly lower in the iBTX group than in the control group (55.0\u00a0mL vs. 116.6\u00a0mL,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>iBTX injection may be safe and effective in reducing sialocele and postoperative drainage in PSP. It might be a useful option to prevent saliva\u2010related complications after PSP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/coa.13767","type":"journal-article","created":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T03:32:53Z","timestamp":1616470373000},"page":"998-1004","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Intraoperative botulinum toxin injection for superficial partial parotidectomy: A prospective pilot study"],"prefix":"10.1111","volume":"46","author":[{"given":"Dong\u2010Joo","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Pusan National University Hospital Busan South Korea"},{"name":"Biomedical Research Institute, Pusan National University Hospital Busan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Mi","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Pusan National University Hospital Busan South Korea"},{"name":"Biomedical Research Institute, Pusan National University Hospital Busan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye\u2010Jin","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Pusan National University Hospital Busan South Korea"},{"name":"Biomedical Research Institute, Pusan National University Hospital Busan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Woo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Pusan National University Hospital Busan South Korea"},{"name":"Biomedical Research Institute, Pusan National University Hospital Busan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7292-9474","authenticated-orcid":false,"given":"Wonjae","family":"Cha","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Seoul National University Bundang Hospital Seoul National University College of Medicine Seongnam South 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