{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T12:09:52Z","timestamp":1787141392291,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T00:00:00Z","timestamp":1620259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To carry out a meta\u2010analysis of prospective literature comparing the clinical efficacy of elective neck dissection (END) vs observation (OBS) in patients with early\u2010stage cT1\/T2N0 tongue carcinoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design\/Setting\/Participants\/Outcome Measures<\/jats:title>\n                    <jats:p>We systematically reviewed four databases from inception to 30\u2010October\u20102020. We considered all studies meeting the following PICOS conditions: (a) Patients: early\u2010stage cT1\/T2N0 tongue carcinoma, (b) Intervention: END, (c) Comparator: OBS, (d) Outcomes: local tongue recurrence, cervical nodal recurrence, disease\u2010specific survival (DSS) rate, and disease\u2010free survival (DFS) rate and (e) Study design: prospective reports. We pooled dichotomous data as relative risks (RRs) with 95% confidence intervals (CIs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Four studies (one case\u2010control study and three randomised controlled trials) met our inclusion criteria. There were 448 eligible patients (225 and 223 patients were treated with END and OBS, respectively). END significantly correlated with improved DSS rate (RR\u00a0=\u00a01.15, 95% CI: 1.04\u20101.27,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.007). Nonetheless, there were no significant differences between END and OBS groups regarding the rates of local tongue recurrence (RR\u00a0=\u00a01.23, 95% CI: 0.50\u20103.03,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.65), cervical nodal recurrence (RR\u00a0=\u00a00.45, 95% CI: 0.16\u20101.27,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.13) and DFS rate (RR\u00a0=\u00a01.08, 95% CI: 0.91\u20101.27,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.38). Pooled analysis for cervical nodal recurrence was heterogeneous, and sensitivity analysis revealed a significantly lower cervical nodal recurrence rate in favour of END group (RR\u00a0=\u00a00.30, 95% CI: 0.13\u20100.67,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.004).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>END correlated with a significant decrease in cervical nodal recurrence and improved DSS rate. END might be superior to OBS in patients with early\u2010stage cT1\/T2N0 tongue cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/coa.13781","type":"journal-article","created":{"date-parts":[[2021,4,11]],"date-time":"2021-04-11T06:40:22Z","timestamp":1618123222000},"page":"720-728","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Elective node dissection versus observation for management of patients with early\u2010stage cT1\/T2N0 tongue carcinoma: A systematic review and meta\u2010analysis of prospective studies"],"prefix":"10.1111","volume":"46","author":[{"given":"Albaraa Y.","family":"Alsini","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head &amp; Neck Surgery AlHada Armed Forces Hospital Taif Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hemail M.","family":"Alsubaie","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head &amp; Neck Surgery King Abdullah Medical City Makkah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hani Z.","family":"Marzouki","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head &amp; Neck Surgery King Abdulaziz University Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2286-2181","authenticated-orcid":false,"given":"Ahmed","family":"Abu\u2010Zaid","sequence":"additional","affiliation":[{"name":"Department of Surgery College of Medicine Alfaisal University Riyadh Saudi Arabia"},{"name":"College of Graduate Health Sciences University of Tennessee Health Science Center Memphis TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalid","family":"Al\u2010Qahtani","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head &amp; Neck Surgery College of Medicine King Saud University Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,6]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2008.06.002"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10004"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-1482.186696"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/lio2.301"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2016.1281"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20988"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2016.03.007"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2006.11.016"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2008.02.017"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000195366.91395.9b"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(89)90122-0"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21033"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.dmfr.4600615"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199710)19:7<583::AID-HED4>3.0.CO;2-3"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(98)00294-3"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000209151.78362.d0"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.129.1.83"},{"key":"e_1_2_13_20_1","first-page":"1","article-title":"Elective neck dissection versus observation in cT1\u2013T2 oral tongue squamous cell carcinoma: a meta\u2010analysis of 11,973 Patients","volume":"1","author":"Akheel M","year":"2020","journal-title":"Indian J Otolaryngol and Head Neck. 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