{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:57:21Z","timestamp":1790024241215,"version":"4.0.1"},"reference-count":46,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T00:00:00Z","timestamp":1626912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine the serum hypoxia\u2010inducible factor\u20101, \u20102 and \u20103 (HIF\u20101, \u20102 and \u20103) levels in patients with laryngeal neoplasm, and to investigate their role in differential diagnosis, prediction of tumour characteristic and extension, and prognosis and survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Prospective, cohort study at a tertiary referral centre.<\/jats:p><\/jats:sec><jats:sec><jats:title>Settings<\/jats:title><jats:p>The study was conducted in a tertiary medical centre.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Patients with benign, premalignant and malignant laryngeal neoplasms were included. Sixty\u2010four patients with a laryngeal neoplasm were enrolled.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>Serum HIF\u20101, \u20102 and \u20103 levels were measured from blood samples that were drawn before treatment, using ELISA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A statistically significant difference between benign (HIF\u20101, \u20102, \u20103:4046,1\u00a0pg\/mL; 2581,5\u00a0pg\/mL; 1321,0\u00a0pg\/mL), premalignant (HIF\u20101, \u20102, \u20103:3630,3\u00a0pg\/mL; 3229,7\u00a0pg\/mL; 2549,8\u00a0pg\/mL) and malignant (HIF\u20101, \u20102, \u20103:3576,7\u00a0pg\/mL; 2595,8\u00a0pg\/mL; 1106,3\u00a0pg\/mL) laryngeal neoplasms was not detected when serum HIF\u20101, \u20102 and \u20103 levels were compared. However, high serum HIF\u20102 level adversely affected survival and locoregional control and had more than 7\u2010fold increase in hazard ratio. Moreover, serum HIF\u20102 was an independent prognostic factor for 2\u2010year overall, disease\u2010free, distant metastasis\u2010free survival and locoregional control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This is the first clinical study in which the diagnostic, predictive and prognostic roles of hypoxia\u2010related biomolecules were examined in laryngeal neoplasms. Hypoxia\u2010inducible factor\u20102 is a prognostic factor in larynx cancer irrespective of treatment modality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.13789","type":"journal-article","created":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T07:55:21Z","timestamp":1619596521000},"page":"1172-1183","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Serum hypoxia\u2010inducible factor\u20102: A candidate prognostic biomarker for laryngeal cancer"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3125-8288","authenticated-orcid":false,"given":"G\u00f6rkem","family":"Eskiizmir","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head Neck Surgery Manisa Celal Bayar University  Manisa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gizem","family":"\u00c7al\u0131ba\u015f\u0131 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