{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T20:47:34Z","timestamp":1769114854515,"version":"3.49.0"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T00:00:00Z","timestamp":1626825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The British Thyroid Association (BTA) recommends ultrasound assessment of thyroid nodules using the U classification. The American College of Radiologists (ACR) recommend assessment with the Thyroid Imaging Reporting and Data System (TIRADS). We conduct the first UK study to compare these two systems.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ultrasound (US) reports of patients who underwent surgical excision of thyroid nodules over a 10\u2010year period in one UK centre were reviewed. US findings were collected, and the classifications were retrospectively applied. The systems were compared to histopathological diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>308 nodules in 296 patients are included. 135 nodules (43.8%) were malignant. U classification showed sensitivity of 88.1% in recommending FNA, significantly higher than TIRADS at 73.3% (<jats:italic>p\u00a0<\/jats:italic>=\u00a0.0002). The U classification showed specificity of 41.6%, significantly lower than TIRADS at 64.2% (p=&lt;0.0001). PPV between classifications at equivalent levels showed no significant difference at U3\/TR\u20103 (<jats:italic>p<\/jats:italic>=.81), U4\/TR\u20104 (<jats:italic>p<\/jats:italic>=.30) or U5\/TR\u20105 (<jats:italic>p<\/jats:italic>=.90).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Classification systems enable risk stratification of potentially malignant thyroid nodules. This study shows BTA U classification has a higher sensitivity but lower specificity than TIRADS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.13831","type":"journal-article","created":{"date-parts":[[2021,6,28]],"date-time":"2021-06-28T17:20:15Z","timestamp":1624900815000},"page":"1286-1289","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Comparing ultrasound assessment of thyroid nodules using BTA U classification and ACR TIRADS measured against histopathological diagnosis"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5279-4138","authenticated-orcid":false,"given":"Simon","family":"McClean","sequence":"first","affiliation":[{"name":"Hull York Medical School Hull University Teaching Hospitals NHS Trust"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugene","family":"Omakobia","sequence":"additional","affiliation":[{"name":"Department of ENT and Head &amp; Neck Surgery Bradford Teaching Hospitals NHS Foundation Trust"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. James A.","family":"England","sequence":"additional","affiliation":[{"name":"Department of ENT and Head &amp; Neck Surgery Hull University Teaching Hospitals NHS Trust"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,7,21]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2014.0353"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacr.2017.01.046"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12515"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2016.17.3.370"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2373050220"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2015.0020"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.7863\/ultra.16.03043"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.21037\/gs.2016.12.14"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018-01674"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2018171074"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.11622\/smedj.2018062"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2017-01708"},{"key":"e_1_2_5_14_1","volume-title":"Stata Statistical Software","author":"StataCorp","year":"2019"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-018-1817-8"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/1742271X19865001"},{"issue":"5","key":"e_1_2_5_17_1","first-page":"263","article-title":"Reliability of the ultrasound classification system of thyroid nodules in predicting malignancy","volume":"73","author":"Ghani FA","year":"2018","journal-title":"Med J Malaysia"},{"key":"e_1_2_5_18_1","first-page":"222","article-title":"Diagnostic accuracy of ultrasound u classification system of thyroid ultrasound in predicting thyroid malignancy by using histopathology as gold standard","volume":"14","author":"Akhter T","year":"2018","journal-title":"Ann Pak Inst Med Sci"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2019.05.026"}],"container-title":["Clinical Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/coa.13831","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/coa.13831","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/coa.13831","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T03:17:52Z","timestamp":1693279072000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/coa.13831"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,21]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["10.1111\/coa.13831"],"URL":"https:\/\/doi.org\/10.1111\/coa.13831","archive":["Portico"],"relation":{},"ISSN":["1749-4478","1749-4486"],"issn-type":[{"value":"1749-4478","type":"print"},{"value":"1749-4486","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,21]]},"assertion":[{"value":"2020-08-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}