{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:41:26Z","timestamp":1791380486357,"version":"4.3.3"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,8,6]],"date-time":"2021-08-06T00:00:00Z","timestamp":1628208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the published time to extrusion of tympanostomy tubes inserted in the various quadrants of the tympanic membrane.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Publications were selected by a search with \u2018PubMed\u2019, \u2018Embase\u2019 and \u2018Web of Science\u2019. A meta\u2010analysis of time to extrusion as a function of tympanic membrane quadrant intubation was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design, Setting, Participant\u2010Not relevant Main Outcome Measured<\/jats:title><jats:p>Extrusion rate of tympanostomy tubes inserted in the various quadrants of the tympanic membrane.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eleven studies describing 2232 tympanostomy tubes were enrolled into the quantitative meta\u2010analysis. The extrusion rate was evaluated at 3\u2010month intervals up to 24 months post\u2010intubation, and it did not differ significantly at any of the time points tested for the superior and inferior anterior quadrants. The cumulative extrusion rates were as follows: 11 and 9%, 32 and 23%, 59 and 36%, 80 and 67%, 87 and 70%, 88 and 82%, and 96 and 89% in the superior and anterior quadrants, respectively, at 3, 6, 9, 15, 18, 21 and 24 months post\u2010intubation, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Time to extrusion of tympanostomy tubes are similar for all 3 tympanic membrane quadrants. The anterior superior quadrant intubation has no superiority in terms of intubation time.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.13843","type":"journal-article","created":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T18:46:04Z","timestamp":1627670764000},"page":"1165-1171","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Meta\u2010analysis of time to extrusion of tympanostomy tubes by tympanic membrane quadrant"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5904-1291","authenticated-orcid":false,"given":"Omer J.","family":"Ungar","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head, Neck and Maxillofacial Surgery Tel Aviv Sourasky Medical Center Affiliated to the Sackler School of Medicine Tel Aviv University Tel Aviv 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