{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T20:06:01Z","timestamp":1777320361213,"version":"3.51.4"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,8,20]],"date-time":"2021-08-20T00:00:00Z","timestamp":1629417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81902753"],"award-info":[{"award-number":["81902753"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>We aimed to quantitatively evaluate the degree of endolymphatic hydrops and its correlation with the clinical features of Meniere\u2019s disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively collected data from patients with Meniere\u2019s disease who underwent gadolinium\u2010enhanced magnetic resonance imaging (MRI) at our department from January 2018 to December 2019. Mimics software was used to perform three\u2010dimensional modelling of the labyrinth, and volume information was obtained to calculate the endolymphatic hydrops index (EHI). A correlation analysis was conducted with data from pure tone audiometry, electrocochleography (EchoG), vestibular myogenic\u2010evoked potential (VEMP) testing, caloric testing and video head impulse testing (vHIT). A two\u2010dimensional method was also employed to calculate the hydrops ratio (HR) of cochlea and vestibule. The test\u2010retest reliability of EHI\/HR from different operators was evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 23 affected ears were examined, and the EHI was significantly correlated with Meniere\u2019s disease stage, low\u2010frequency hearing threshold, EchoG summating potential\/action potential ratio (\u2212SP\/AP) and VEMP binaural asymmetry ratio, but no significant correlation was observed between EHI and the caloric test or vHIT. The Intraclass correlation coefficient (ICC) of EHI data calculated by two otologists was 0.946 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). And the ICC of cochlea and vestibule HR were 0.844 and 0.832 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Mimics software can be used to quantitatively evaluate the degree of endolymphatic hydrops and have shown higher test\u2010retest reliability than traditional two\u2010dimensional evaluation method. Endolymphatic hydrops correlates with clinical data, such as Meniere's disease stage, low\u2010frequency hearing threshold, EchoG and VEMP asymmetry ratio.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.13847","type":"journal-article","created":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T08:33:08Z","timestamp":1628843588000},"page":"1354-1361","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Quantification of endolymphatic hydrops and its correlation with Meniere\u2019s disease clinical features"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2976-8318","authenticated-orcid":false,"given":"Qiyang","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology The First Affiliated Hospital Sun Yat\u2010sen University Guangzhou China"},{"name":"Institute of Otorhinolaryngology Sun Yat\u2010sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangli","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology The First Affiliated Hospital Sun Yat\u2010sen University Guangzhou China"},{"name":"Institute of Otorhinolaryngology Sun Yat\u2010sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guanxia","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology The First Affiliated Hospital Sun Yat\u2010sen University Guangzhou China"},{"name":"Institute of Otorhinolaryngology Sun Yat\u2010sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology The First Affiliated Hospital Sun Yat\u2010sen University Guangzhou China"},{"name":"Institute of Otorhinolaryngology Sun Yat\u2010sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiping","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology The First Affiliated Hospital Sun Yat\u2010sen University Guangzhou China"},{"name":"Institute of Otorhinolaryngology Sun Yat\u2010sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fanqin","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology The First Affiliated Hospital Sun Yat\u2010sen University Guangzhou China"},{"name":"Institute of Otorhinolaryngology Sun Yat\u2010sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,8,20]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2005.06.015"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2010.05.001"},{"key":"e_1_2_12_4_1","first-page":"2310","article-title":"On the pathological change in a patient with Meniere\u2019s disease [in German]. 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