{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T11:04:57Z","timestamp":1770462297942,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,11,7]],"date-time":"2021-11-07T00:00:00Z","timestamp":1636243200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We performed a systematic review on single\u2010nucleotide polymorphisms and risk\u2010related chronic rhinosinusitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and Setting<\/jats:title><jats:p>A comprehensive review of the last 20\u00a0years\u2019 English language literature regarding chronic rhinosinusitis and single\u2010nucleotide polymorphisms was performed. We included in the synthesis all the papers reporting gene variation implicated in the pathogenesis of chronic inflammation and polyps.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found 12 papers with 9127 patients, of which 2739 CRS cases and 6388 controls. The major comorbidities reported related to chronic rhinosinusitis were atopy in 4555 (49.9%), asthma in 4594 (50.33%), Samter Triad in 448 (4.9%) and eosinophilia in 391 subjects (4.28%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our systematic review revealed the major SNPs significantly associated with chronic rhinosinusitis and the specific pathways involved. Given the presence of different extraction methods and samples sequencing, further studies with larger courts are necessary to identify significative single\u2010nucleotide polymorphisms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.13870","type":"journal-article","created":{"date-parts":[[2021,10,2]],"date-time":"2021-10-02T07:48:30Z","timestamp":1633160910000},"page":"14-23","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Single\u2010nucleotide polymorphism in chronic rhinosinusitis: A systematic review"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1251-0185","authenticated-orcid":false,"given":"Maniaci","family":"Antonino","sequence":"first","affiliation":[{"name":"Department of Medical and Surgical Sciences and Advanced Technologies \"GF Ingrassia\" ENT Section ENT Department of University of Catania Catania Italy"},{"name":"Department of Biomedical and Biotechnological Sciences (BIOMETEC) University of Catania Catania Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Musso","family":"Nicol\u00f2","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Biotechnological Sciences (BIOMETEC) University of Catania Catania Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0845-0845","authenticated-orcid":false,"given":"Lechien","family":"Jerome Renee","sequence":"additional","affiliation":[{"name":"Research Committee of the Young Otolaryngologists International Federations of ORL Societies Paris France"},{"name":"Department of Human Anatomy and Experimental Oncology School of Medicine UMONS Research Institute for Health Sciences and Technology University of Mons Mons Belgium"},{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery CHU Saint\u2010Pierre School of Medicine Universit\u00e9 Libre de Bruxelles Brussels Belgium"},{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Foch Hospital University of Paris\u2010Saclay) Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merlino","family":"Federico","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences and Advanced Technologies \"GF Ingrassia\" ENT Section ENT Department of University of Catania Catania Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viglianisi","family":"Chiara","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences and Advanced Technologies \"GF Ingrassia\" ENT Section ENT Department of University of Catania Catania Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stracquadanio","family":"Stefano","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Biotechnological Sciences (BIOMETEC) Medical Molecular Microbiology and Antibiotic Resistance Laboratory (MMARLab) University of Catania Catania Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santagati","family":"Maria","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Biotechnological Sciences (BIOMETEC) Medical Molecular Microbiology and Antibiotic Resistance Laboratory (MMARLab) University of Catania Catania Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cocuzza","family":"Salvatore","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences and Advanced Technologies \"GF Ingrassia\" ENT Section ENT Department of University of Catania Catania Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bonanno","family":"Antonio","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences and Advanced Technologies \"GF Ingrassia\" ENT Section ENT Department of University of Catania Catania Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3580-0967","authenticated-orcid":false,"given":"Christian","family":"Calvo\u2010Henriquez","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Task Force COVID\u201019 of the Young\u2010Otolaryngologists of the International Federations of Oto\u2010Rhino\u2010Laryngological Societies (YO\u2010IFOS) Hospital Complex of Santiago de Compostela Santiago de Compostela Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefani","family":"Stefania","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Biotechnological Sciences (BIOMETEC) Medical Molecular Microbiology and Antibiotic Resistance Laboratory (MMARLab) University of Catania Catania Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignazio","family":"La Mantia","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences and Advanced Technologies \"GF Ingrassia\" ENT Section ENT Department of University of Catania Catania Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,11,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin20.600"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.11.013"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13373"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2017.02.002"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2019.08.010"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2016.08.009"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2009.219"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxs162"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102350\u20109\u201021"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.26619"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21275"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23300"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0089329"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000499875"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/2046\u20104053\u20104\u20101"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472\u20106947\u20107\u201016"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l6890"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-155-8-201110180-00009"},{"key":"e_1_2_10_20_1","article-title":"Chapter 7: systematic reviews of etiology and risk","author":"Moola S","year":"2017","journal-title":"Rev Man Joanna Briggs Inst"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0158202"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2010.24.3429"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.134.8.852"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102350\u201011\u201085"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0039247"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21591"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin20.055"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102249.1990.tb03286.x"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010018\u20100449\u20108"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin19.403"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2015.29.4241"}],"container-title":["Clinical Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/coa.13870","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/coa.13870","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/coa.13870","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T07:27:30Z","timestamp":1692862050000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/coa.13870"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,7]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1111\/coa.13870"],"URL":"https:\/\/doi.org\/10.1111\/coa.13870","archive":["Portico"],"relation":{},"ISSN":["1749-4478","1749-4486"],"issn-type":[{"value":"1749-4478","type":"print"},{"value":"1749-4486","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,7]]},"assertion":[{"value":"2021-06-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}