{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T01:32:04Z","timestamp":1769304724528,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T00:00:00Z","timestamp":1637020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess long\u2010term outcomes of ALA\u2010PDT in treating recalcitrant laryngeal leukoplakia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study design<\/jats:title><jats:p>Retrospective Case\u2010Control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed all laryngeal leukoplakia patients treated with ALA\u2010PDT compared with angiolytic laser treatment alone (585\u00a0nm PDL or 532\u00a0nm KTP laser) from 2000 to 2019. Patients with laryngeal cancer (or a history of laryngeal cancer), leukoplakia previously treated with radiation and no pathologic report were excluded. Patient demographics, procedure details and outcomes were examined including histopathologic diagnosis, procedures performed, ALA usage, recurrence of leukoplakia and the development of cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 132 patients with laryngeal leukoplakia: 42 were treated with ALA\u2010PDT and 90 were treated with an angiolytic laser alone (Laser group). The proportion of cases of high\u2010grade dysplasia was 57.1% in the ALA\u2010PDT group compared to 32.2% in the Laser group. In high\u2010grade dysplasia cases, there was a statistically significant better recurrence\u2010free survival (RFS) at 12\u00a0months and 60\u00a0months in those who underwent ALA\u2010PDT 71.4% and 7.1% vs Laser 25% and 0% (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.01). However, for overall groups, there was no difference in RFS (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.25). Voice outcomes (patient subjective report) improved or were stable in 75% of subjects with no serious side effects reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>ALA\u2010PDT for recalcitrant and high\u2010grade dysplasia is highly effective with improved recurrence\u2010free survival compared to laser alone. ALA\u2010PDT may be an appropriate therapy in patients who have failed prior angiolytic laser alone.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.13878","type":"journal-article","created":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T00:34:19Z","timestamp":1637109259000},"page":"153-159","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Long\u2010term outcomes of aminolevulinic acid photodynamic therapy for treatment of recalcitrant laryngeal premalignant lesions"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5592-0849","authenticated-orcid":false,"given":"Alena","family":"Santeerapharp","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Faculty of Medicine Srinakharinwirot University Bangkok Thailand"},{"name":"Department of Otolaryngology Massachusetts Eye and Ear Boston Massachusetts 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