{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:12:56Z","timestamp":1787065976663,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,11,14]],"date-time":"2021-11-14T00:00:00Z","timestamp":1636848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2016R1A5A2008630"],"award-info":[{"award-number":["2016R1A5A2008630"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102021R1A2C2010811"],"award-info":[{"award-number":["NRF\u20102021R1A2C2010811"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102016M3A9D5A01952414"],"award-info":[{"award-number":["NRF\u20102016M3A9D5A01952414"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the association between physician\u2010diagnosed diabetes mellitus (DM) and chronic rhinosinusitis (CRS) phenotypes in a national population\u2010based study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Retrospective cross\u2010sectional study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Population\u2010based survey data were collected by the Korean National Health and Nutrition Survey between January 2008 and December 2012.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants and Methods<\/jats:title>\n                    <jats:p>A total of 34\u00a0670 participants aged over 19\u00a0years were enrolled in the Korea National Health and Nutrition Examination Surveys from 2008 to 2012. The relationship of CRS prevalence, with and without nasal polyps, with physician\u2010diagnosed DM and non\u2010DM were assessed. Differences in sinonasal symptoms between patients with and without DM were analysed in this cross\u2010sectional study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A significant association was observed between DM and CRS with nasal polyps after adjustment for multiple variables. No substantial association was observed between DM and CRS without nasal polyps. Among patients with CRS, olfactory dysfunction for &gt;3\u00a0months was significantly more frequent in the DM group than in the non\u2010DM group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We demonstrated significant associations between DM and CRS with nasal polyps and olfactory dysfunction among patients with CRS in a large national clinical cohort study. The direct mechanism of the association between DM and CRS with nasal polyps should be further investigated to clarify the pathogenesis of CRS with nasal polyps.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/coa.13884","type":"journal-article","created":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T22:12:55Z","timestamp":1635804775000},"page":"167-173","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Association between diabetes mellitus and chronic rhinosinusitis with nasal polyps: A population\u2010based cross\u2010sectional study"],"prefix":"10.1111","volume":"47","author":[{"given":"Jae\u2010Sung","family":"Nam","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Yonsei University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun\u2010Ho","family":"Roh","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics Yonsei University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jungghi","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Yonsei University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suk\u2010Won","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Yonsei University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong\u2010Gyun","family":"Ha","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Yonsei University Yongin Severance Hospital Yongin Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong\u2010Jin","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Yonsei University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wasan Almazouq","family":"Fahad","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Imam Abdulrahman bin Faisal University Dammam Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joo\u2010Heon","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Yonsei University College of Medicine Seoul Korea"},{"name":"Airway Mucus Institute Yonsei University College of Medicine Seoul Korea"},{"name":"Korea Mouse Sensory Phenotyping Center Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1238-6396","authenticated-orcid":false,"given":"Chang\u2010Hoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Yonsei University College of Medicine Seoul Korea"},{"name":"Airway Mucus Institute Yonsei University College of Medicine Seoul Korea"},{"name":"Korea Mouse Sensory Phenotyping Center Seoul Korea"},{"name":"Taste Research Center Yonsei University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2851-3225","authenticated-orcid":false,"given":"Hyung\u2010Ju","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Yonsei University College of Medicine Seoul Korea"},{"name":"Airway Mucus Institute Yonsei University College of Medicine Seoul Korea"},{"name":"Korea Mouse Sensory Phenotyping Center Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2016.30.4297"},{"key":"e_1_2_11_3_1","unstructured":"FokkensWJ LundVJ MullolJ et al.European Position Paper on Rhinosinusitis and Nasal Polyps 2012. 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