{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T23:55:06Z","timestamp":1784159706683,"version":"3.55.0"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,11,21]],"date-time":"2021-11-21T00:00:00Z","timestamp":1637452800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008376","name":"Helsingin ja Uudenmaan Sairaanhoitopiiri","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008376","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Postoperative infection is the most common complication after septoplasty. Pre\u2010 or postoperative prophylactic antibiotics are commonly used, although no official guidelines exist.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>We retrospectively collected data on postoperative infections from 772 septoplasties performed in 2015, 2016 and 2018, and classified the infections according to surgical site infection (SSI) criteria by the Centers for Disease Control and Prevention (CDC). We evaluated the infections according to antibiotic use (preoperative or postoperative, both, or none) and accounted for patient and surgical confounding factors. We compared the results with three previous studies from our department to find out the trend in the occurrence of postoperative infections and in the use of antibiotics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010nine cases (3.8%) fulfilled CDC infection criteria. Any kind of antibiotic prophylaxis reduced the risk of SSI (<jats:italic>p\u00a0<\/jats:italic>=\u00a0.018). One dose of intravenous cefuroxime before incision was the most effective preventive measure (<jats:italic>p\u00a0<\/jats:italic>=\u00a0.045). We found no significant effect of postoperative antibiotics. However, postoperative antibiotics lowered the infection rate to 1.8% compared to 6.1% among those not treated with any antibiotics. The only other factor reducing the risk of SSI was local anaesthesia compared with general anaesthesia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Preoperative antibiotic prophylaxis effectively reduced postoperative infection rate after septoplasty.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.13889","type":"journal-article","created":{"date-parts":[[2021,11,6]],"date-time":"2021-11-06T18:03:46Z","timestamp":1636221826000},"page":"174-180","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["One dose of preoperative, intravenous, prophylactic antibiotics significantly lowers postoperative infection rate in septoplasty\u2014a study of 772 operations"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7803-5826","authenticated-orcid":false,"given":"Marie","family":"Lundberg","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology \u2010 Head and Neck Surgery Helsinki University Hospital and University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1781-1718","authenticated-orcid":false,"given":"Markus","family":"Lilja","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2010 Head and Neck Surgery Helsinki University Hospital and University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8381-9174","authenticated-orcid":false,"given":"Karin","family":"Blomgren","sequence":"additional","affiliation":[{"name":"HUS Joint Resources Helsinki University Hospital and University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9888-3128","authenticated-orcid":false,"given":"Ida","family":"Kotisalmi","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2010 Head and Neck Surgery Helsinki University Hospital and University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0451-2404","authenticated-orcid":false,"given":"Antti A.","family":"M\u00e4kitie","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2010 Head and Neck Surgery Helsinki University Hospital and University of Helsinki Helsinki Finland"},{"name":"Division of Ear, Nose, and Throat Diseases Department of Clinical Sciences, Intervention, and Technology Karolinska Institutet and Karolinska University Hospital Stockholm Sweden"},{"name":"Faculty of Medicine Research Program in Systems Oncology University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3987-412X","authenticated-orcid":false,"given":"Sara","family":"Sainio","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2010 Head and Neck Surgery Helsinki University Hospital and University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4251-7879","authenticated-orcid":false,"given":"Maija","family":"Hyt\u00f6nen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2010 Head and Neck Surgery Helsinki University Hospital and University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,21]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"Global Guidelines on the Prevention of Surgical Site Infection","year":"2016"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2016.12.016"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhino09.177"},{"issue":"4","key":"e_1_2_11_5_1","first-page":"273","article-title":"Complications and number of follow\u2010up visits after using septal stapler in septoplasty","volume":"57","author":"Sainio S","year":"2019","journal-title":"Rhinol"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/000164800454297"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003489419867976"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-018-4990-8"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459989210600307"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-4486.2006.01139.x"},{"issue":"9","key":"e_1_2_11_11_1","first-page":"495","article-title":"Prevention of surgical site infections","volume":"35","author":"Mockford K","year":"2017","journal-title":"Surg"},{"key":"e_1_2_11_12_1","unstructured":"National Healthcare Safety Network Centers for Disease Control and Prevention.Surgical site infection (SSI) event.http:\/\/www.cdc.gov\/nhsn\/pdfs\/pscmanual\/9pscssicurrent.pdf."},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2017.31.4454"},{"issue":"4","key":"e_1_2_11_14_1","first-page":"267","article-title":"The role of antibiotics in rhinoplasty and septoplasty: a literature review","volume":"46","author":"Georgiou I","year":"2008","journal-title":"Rhinol"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/194589240101500506"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjorl.2015.11.008"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1986.03780030093019"},{"key":"e_1_2_11_18_1","first-page":"1543","article-title":"Antibiotics and the human gut 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