{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T20:40:29Z","timestamp":1768941629802,"version":"3.49.0"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,1,13]],"date-time":"2022-01-13T00:00:00Z","timestamp":1642032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The literature on the entity of the anterior larynx (AL) is restricted to little evidence on the difficulty encountered in exposing the larynx for intubation, perioperative morbidity and mortality, and scant reports on its prevalence in general adults and children. Here, we describe the prevalence of AL in a series of children presenting with aerodigestive symptoms and explore its association with functional abnormalities, congenital and structural anomalies or conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Tertiary paediatric centre.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective case\u2013control study. Using a prospectively collected surgical database, we identified patients diagnosed with AL (Grades IIb\u2010III\u2010IV Modified Cormack\u2010Lehane scale) and sex and age\u2010matched controls who had undergone full airway endoscopy for aerodigestive symptoms. We collected the demographics, presentations, associated diagnoses and investigations. We compared the proportion of patients with large airway abnormalities and dysmorphism and estimated the prevalence of AL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Over a 5.5\u2010year period, 58 children with AL (28 females, mean age 0.38\u00a0years) were matched with 58 controls (mean age 0.42\u00a0years). Although both groups presented with permutations of stridor, respiratory failure, cyanotic spells, swallowing and feeding difficulties and SDB, AL presented much more with swallowing and feeding problems (33 vs. 20, <jats:italic>p\u00a0<\/jats:italic>&lt;\u00a0.05). There were significantly more children with dysmorphism in the AL group (29 vs. 9, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05). The prevalence of AL was 4.9% (SE 0.0063).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>AL was detected in 4.9% of a sample of children who had undergone airway examination for aerodigestive symptoms. It is significantly associated with dysmorphism, and swallowing difficulties that warrant instrumental evaluation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.13908","type":"journal-article","created":{"date-parts":[[2021,12,26]],"date-time":"2021-12-26T07:33:43Z","timestamp":1640504023000},"page":"313-318","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Paediatric anterior larynx: presentations, associations and a review of the literature"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8902-7036","authenticated-orcid":false,"given":"Hussein","family":"Smaily","sequence":"first","affiliation":[{"name":"Division of Otolaryngology\u2013Head &amp; Neck Surgery Department of Surgery The Stollery Children\u2019s Hospital University of Alberta Hospital  Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ismaeel","family":"El\u2010Hakim","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2013Head &amp; Neck Surgery Department of Surgery The Stollery Children\u2019s Hospital University of Alberta Hospital  Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamdy","family":"El\u2010Hakim","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2013Head &amp; Neck Surgery Department of Surgery The Stollery Children\u2019s Hospital University of Alberta Hospital  Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,1,13]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000051699.24104.85"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/aas.13387"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2012.03813.x"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(15)00508-1"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2011.03555.x"},{"key":"e_1_2_12_7_1","first-page":"37","article-title":"chute de la base de la langue consideree comme une nouvelle cause de gene dans la respiration naso\u2010pharyngienne","volume":"89","author":"La RP","year":"1923","journal-title":"Bull Acad Med Paris"},{"key":"e_1_2_12_8_1","unstructured":"Best Practices for the Diagnosis and Evaluation of Infants With Robin Sequence: A Clinical Consensus Report | Congenital Defects. 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