{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T20:16:10Z","timestamp":1780517770570,"version":"3.54.1"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,1,23]],"date-time":"2022-01-23T00:00:00Z","timestamp":1642896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Three\u2010dimensional inversion\u2010recovery sequence with real reconstruction (3D\u2010real IR) magnetic resonance imaging (MRI) can detect endolymphatic hydrops of the inner ear. We aimed to explore a appropriate dose for intravenous gadolinium injection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Observational prospective study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Tertiary referral centre.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>We collected 90 unilateral definite Meniere's disease patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>All enrolled patients were divided into three groups randomly (patients in group A, B and C received gadolinium injection in 1\/1.5\/2 times doses respectively). After 4\u00a0h, inner ear MRI scans were applied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The signal intensities of B\u2010affected ears and C\u2010affected ears were significantly higher than A\u2010affected ears (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05); however, no difference was found between B\u2010affected ears and C\u2010affected ears (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.267). The same conditions also appeared in the three unaffected\u2010ear groups. Moreover, the signal intensities of affected\u2010ear in group A, B and C were significantly higher than that of the corresponding unaffected\u2010ear groups (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05). Besides, the subjective visual evaluation scores of group B and C were significantly better than that of group A (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Intravenous injection of gadolinium in a single dose may be unbefitting for the inner ear imaging based on 3D\u2010real IR MRI, both the applications of gadolinium in 1.5 times and double doses can have a good perilymphatic enhancement effect of inner ear. In order to minimise the use of dose for avoiding or mitigating the adverse reactions and renal damage, 1.5 times dose may be preferred in clinical practice.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.13912","type":"journal-article","created":{"date-parts":[[2022,1,16]],"date-time":"2022-01-16T11:39:55Z","timestamp":1642333195000},"page":"717-723","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Inner ear MRI enhancement based on three dimensional\u2010real IR sequence in patients with Meniere\u2019s disease after intravenous gadolinium injection: Comparison of different doses used and exploration of an appropriate dose"],"prefix":"10.1111","volume":"47","author":[{"given":"Wei","family":"Chen","sequence":"first","affiliation":[{"name":"Shanghai Institute of Medical Imaging Fudan University  Shanghai China"},{"name":"Department of Interventional Radiology Zhongshan Hospital of Fudan University  Shanghai 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