{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T18:57:08Z","timestamp":1777316228639,"version":"3.51.4"},"reference-count":72,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T00:00:00Z","timestamp":1662336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2023,3]]},"abstract":"Abstract<\/jats:title>\n \n Objectives<\/jats:title>\n To determine the anatomical variations of the lateral nasal wall and anterior skull base amongst populations in different geographical regions.<\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n Systematic review and meta\u2010analysis.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Using PRISMA guidelines, SCOPUS and PUBMED databases were searched from inception until 1 March 2022. The regions and populations identified were from Europe, Asia, Middle East, Australia\u2010New Zealand\u2010Oceania, South America, North America and Africa. Random\u2010effects model was used to estimate the pooled prevalence with 95% confidence intervals (CIs). Heterogeneity was assessed using the\n I<\/jats:italic>\n 2<\/jats:sup>\n statistic and Cochran's\n Q<\/jats:italic>\n test.\n <\/jats:p>\n <\/jats:sec>\n \n Main outcome measures<\/jats:title>\n Anatomical variations of the lateral nasal wall and anterior skull base confirmed by computed tomography scan.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Fifty\u2010six articles were included with a total of 11\u2009805 persons. The most common anatomical variation of the ostiomeatal complex was pneumatization of the agger nasi (84.1%), olfactory fossa was Keros type 2 (53.8%) and ethmoids was asymmetry of the roof (42.8%). Sphenoethmoidal and suprabullar cells have a higher prevalence in North Americans (53.7%, 95% CI: 46.00\u201361.33) while asymmetry of ethmoid roof more common in Middle Easterns (85.5%, 95% CI: .00\u2013100). Bent uncinate process has greater prevalence in Asians while supraorbital ethmoid cells and Keros type 3 more common in non\u2010Asians. The overall studies have substantial heterogeneity and publication bias.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Certain anatomic variants are more common in a specific population. The \u2018approach of analysis\u2019 plays a role in the prevalence estimates and consensus should be made in future studies regarding the most appropriate \u2018approach of analysis\u2019 either by persons or by sides.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/coa.13975","type":"journal-article","created":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T09:58:27Z","timestamp":1661248707000},"page":"271-285","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Radiological anatomical variations of the lateral nasal wall and anterior skull base amongst different populations: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8725-0111","authenticated-orcid":false,"given":"Farah Dayana","family":"Zahedi","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Universiti Kebangsaan Malaysia Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6860-1430","authenticated-orcid":false,"given":"Najib Majdi","family":"Yaacob","sequence":"additional","affiliation":[{"name":"Unit of Biostatistics and Research Methodology, School of Medical Sciences Universiti Sains Malaysia Kubang Kerian Kelantan Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0909-2963","authenticated-orcid":false,"given":"De Yun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9138-9215","authenticated-orcid":false,"given":"Baharudin","family":"Abdullah","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery, School of Medical Sciences Universiti Sains Malaysia Kubang Kerian Kelantan Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,9,5]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin20.601"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20804"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21131"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2015.05.002"},{"issue":"3","key":"e_1_2_13_6_1","first-page":"210","article-title":"Ethnic variation in sinonasal anatomy on CT\u2010scanning","volume":"43","author":"Badia L","year":"2005","journal-title":"Rhinology"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119536604"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.46658\/JBIMES-20-08"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v036.i03"},{"key":"e_1_2_13_11_1","volume-title":"RStudio: Integrated Development for R","author":"RStudio Team","year":"2020"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0000000000001232"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.1230"},{"issue":"6","key":"e_1_2_13_14_1","first-page":"763","article-title":"Anatomical variations of the lateral nasal wall and paranasal sinuses: a CT study for endoscopic sinus surgery (ESS) in Thai patients","volume":"88","author":"Nitinavakarn B","year":"2005","journal-title":"J Med Assoc Thai"},{"issue":"5","key":"e_1_2_13_15_1","first-page":"535","article-title":"Concha bullosa in chronic sinusitis","volume":"60","author":"Subramanian S","year":"2005","journal-title":"Med J Malaysia"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2006.05.750"},{"issue":"6","key":"e_1_2_13_17_1","first-page":"477","article-title":"Anatomic variations of paranasal sinuses in patients with chronic sinusitis and their correlation with CT scan staging","volume":"45","author":"Baradaranfar MH","year":"2007","journal-title":"Acta Med Iran"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2007.06.737"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000114533"},{"issue":"3","key":"e_1_2_13_20_1","first-page":"290","article-title":"Anatomical variations in sino\u2010nasal region: a computer tomography (CT) study","volume":"44","author":"Al\u2010Qudah MA","year":"2010","journal-title":"J Med J"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20977"},{"issue":"2","key":"e_1_2_13_22_1","first-page":"239","article-title":"Prevalence of the uncinate process, agger nasi cell and their relationship in a Taiwanese population","volume":"48","author":"Liu SC","year":"2010","journal-title":"Rhinology"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.3342\/ceo.2010.3.2.76"},{"issue":"1","key":"e_1_2_13_24_1","first-page":"11","article-title":"Variations of the paranasal sinuses in Melanesians as observed by CT","volume":"48","author":"Robinson M","year":"2010","journal-title":"Rhinology"},{"issue":"2","key":"e_1_2_13_25_1","first-page":"108","article-title":"The association of concha bullosa and deviated nasal septum with chronic rhinosinusitis in functional endoscopic sinus surgery patients","volume":"65","author":"Vincent TE","year":"2010","journal-title":"Med J Malaysia"},{"issue":"3","key":"e_1_2_13_26_1","first-page":"191","article-title":"The prevalence of anatomical variations in osteomeatal unit in patients with chronic rhinosinusitis","volume":"66","author":"Azila A","year":"2011","journal-title":"Med J Malaysia"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348941112000903"},{"issue":"9","key":"e_1_2_13_28_1","first-page":"1122","article-title":"The prevalence and pattern of pneumatization of Onodi cell in Thai patients","volume":"94","author":"Kasemsiri P","year":"2011","journal-title":"J Med Assoc Thai"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599811418040"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2011.10.002"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10013-1106"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.5935\/1808-8694.20130052"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.5539\/gjhs.v6n1p135"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2012.07.010"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.5001\/omj.2014.27"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin13.110"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00276-015-1494-8"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.5604\/00306657.1184543"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40463-015-0074-6"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.5455\/gulhane.187255"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.15537\/smj.2016.5.13904"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2017.04.003"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejenta.2016.11.001"},{"issue":"1","key":"e_1_2_13_44_1","first-page":"6","article-title":"Anatomical variations of the nose and paranasal sinuses in Palakkad population using CT scan \u2010 a case control study","volume":"16","author":"Vinodhini P","year":"2017","journal-title":"Online J Health Allied Scs"},{"issue":"4","key":"e_1_2_13_45_1","first-page":"30","article-title":"The evaluation of the anatomical variations of osteomeatal complex in cone beam computed tomography images","volume":"20","author":"Abesi F","year":"2018","journal-title":"J Babol Univ Med Sci"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22105"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.4103\/nmj.NMJ_138_18"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2018.04.010"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-018-4992-6"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2018.05.113"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12070-019-01716-9"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12070-019-01600-6"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.13005\/bpj\/1842"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics10110970"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43055-020-00222-1"},{"issue":"2","key":"e_1_2_13_56_1","first-page":"121","article-title":"Analysis of the anatomic variations of the ethmoid roof among Saudi populations: a radiological study","volume":"24","author":"Madani GA","year":"2020","journal-title":"Eur J Anat"},{"issue":"110","key":"e_1_2_13_57_1","first-page":"169","article-title":"Variations of ethmoid roof in the Iranian population\u2014a cross sectional study","volume":"32","author":"Moradi M","year":"2020","journal-title":"Iran J Otorhinolaryngol"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.4103\/ams.ams_192_19"},{"key":"e_1_2_13_59_1","doi-asserted-by":"crossref","first-page":"368","DOI":"10.4103\/jdmimsu.jdmimsu_124_19","article-title":"Evaluation of anatomical variants in paranasal sinuses with computed tomography in central India region","volume":"15","author":"Parihar P","year":"2020","journal-title":"J Datta Meghe Inst Med Sci Univ"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215120002066"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.5115\/acb.20.247"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.3342\/kjorl-hns.2020.00829"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.3329\/bjms.v20i1.50347"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.2147\/RMI.S291339"},{"issue":"1","key":"e_1_2_13_65_1","first-page":"195","article-title":"A CT\u2010scan review of anatomical variants of sinonasal region and its correlation with symptoms of sinusitis (nasal obstruction, facial pain and rhinorrhea)","volume":"37","author":"Qureshi MF","year":"2021","journal-title":"Pak J Med Sci"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.1159\/000514458"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-021-06843-0"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2008.05.014"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.4103\/njcp.njcp_199_16"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.12659\/PJR.903684"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.12727"},{"issue":"1","key":"e_1_2_13_72_1","first-page":"28","article-title":"Management of rhinosinusitis in adult in primary care","volume":"13","author":"Husain S","year":"2018","journal-title":"Malays Fam Physician"},{"key":"e_1_2_13_73_1","doi-asserted-by":"publisher","DOI":"10.7860\/JCDR\/2014\/9323.4923"}],"container-title":["Clinical Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/coa.13975","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/coa.13975","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/coa.13975","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T01:54:00Z","timestamp":1692323640000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/coa.13975"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,5]]},"references-count":72,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["10.1111\/coa.13975"],"URL":"https:\/\/doi.org\/10.1111\/coa.13975","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/COA.13975\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.13975\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.13975\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.13975\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.13975\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.13975\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.13975\/v3\/decision1","asserted-by":"object"}]},"ISSN":["1749-4478","1749-4486"],"issn-type":[{"value":"1749-4478","type":"print"},{"value":"1749-4486","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,5]]},"assertion":[{"value":"2022-05-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}