{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T04:25:03Z","timestamp":1782275103641,"version":"3.54.5"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T00:00:00Z","timestamp":1663632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100014103","name":"Key Technology Research and Development Program of Shandong","doi-asserted-by":"publisher","award":["2019GSF108248"],"award-info":[{"award-number":["2019GSF108248"]}],"id":[{"id":"10.13039\/100014103","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the clinical characteristics and prognostic factors of simultaneous and sequential bilateral sudden sensorineural hearing loss (Si\u2010BSSNHL and Se\u2010BSSNHL, respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Retrospective case\u2013control study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>A single tertiary referral centre.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Patients diagnosed with unilateral sudden sensorineural hearing loss (USSNHL), Si\u2010BSSNHL, or Se\u2010BSSNHL between September 2018 and November 2019.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main outcome measures<\/jats:title>\n                    <jats:p>Demographic and clinical characteristics, audiological features, laboratory results and hearing recovery were analysed for intergroup comparisons. Prognostic factors for BSSNHL were analysed using univariate and multivariate logistic analyses between the overall and no\u2010recovery groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared to the USSNHL group, a larger final pure\u2010tone average (PTA) (\n                      <jats:italic>H<\/jats:italic>\n                      \u00a0=\u00a038.0 and 53.8, respectively, both adjusted\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value (\n                      <jats:italic>p adj<\/jats:italic>\n                      )\u2009&lt;.05), lower hearing gain (\n                      <jats:italic>H<\/jats:italic>\n                      \u00a0=\u00a0\u221270.8 and\u2009\u2212\u200974.6, respectively, both\n                      <jats:italic>p adj<\/jats:italic>\n                      \u2009&lt;.001) and higher homocysteine levels (\n                      <jats:italic>H<\/jats:italic>\n                      \u00a0=\u00a046.8, 58.8, respectively, both\n                      <jats:italic>p adj<\/jats:italic>\n                      \u2009&lt;.05) were observed in the Si\u2010BSSNHL and Se\u2010BSSNHL groups, while the rate of positive vestibular tests and proportion of tinnitus were lower in the Se\u2010BSSNHL group (\n                      <jats:italic>\u03c7<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a08.5 and 38.1, respectively, both\n                      <jats:italic>p adj<\/jats:italic>\n                      \u2009&lt;0.05). The USSNHL group showed a significant difference in the degree of deafness and therapeutic outcome in the Se\u2010BSSNHL and Si\u2010BSSNHL groups, respectively (\n                      <jats:italic>\u03c7<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a012.4,\n                      <jats:italic>p adj<\/jats:italic>\n                      \u2009&lt;.05; \u03c7\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a013.6;\n                      <jats:italic>p adj<\/jats:italic>\n                      \u2009&lt;.05). Hypertension (95% confidence interval, 1.014\u201328.623,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.05) and onset days (95% confidence interval, 0.007\u20130.626,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.05) were associated with the therapeutic effects of BSSNHL.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Higher homocysteine levels in BSSNHL may implicate microvascular disorders as a causative factor of BSSNHL. Hypertension and onset days were associated with the prognosis of BSSNHL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/coa.13981","type":"journal-article","created":{"date-parts":[[2022,9,10]],"date-time":"2022-09-10T10:33:15Z","timestamp":1662805995000},"page":"732-740","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Characteristics and prognosis analysis of bilateral sudden sensorineural hearing loss: A retrospective case\u2013control study"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6349-5731","authenticated-orcid":false,"given":"Yingjun","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery, Shandong Provincial ENT Hospital, Cheeloo College of Medicine Shandong University  Jinan China"},{"name":"Department of Otology Medicine Shandong Provincial ENT Hospital  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2972-6748","authenticated-orcid":false,"given":"Wenping","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery, Shandong Provincial ENT Hospital, Cheeloo College of Medicine Shandong University  Jinan China"},{"name":"Department of Otology Medicine Shandong Provincial ENT Hospital  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery, Shandong Provincial ENT Hospital, Cheeloo College of Medicine Shandong University  Jinan China"},{"name":"Department of Otology Medicine Shandong Provincial ENT Hospital  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenwen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery, Shandong Provincial ENT Hospital, Cheeloo College of Medicine Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaomin","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery, Shandong Provincial ENT Hospital, Cheeloo College of Medicine Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery, Shandong Provincial ENT Hospital, Cheeloo College of Medicine Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingming","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery, Shandong Provincial ENT Hospital, Cheeloo College of Medicine Shandong University  Jinan China"},{"name":"Department of Otology Medicine Shandong Provincial ENT Hospital  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,20]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2004.09.072"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)62071-7"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2006.05.015"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/0366-6999.223843"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000107435"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199611000-00008"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/S002221511300306X"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25333"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/01677063.2011.652266"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21197248"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000002287"},{"issue":"6","key":"e_1_2_14_13_1","first-page":"443","article-title":"Guideline of diagnosis and treatment of sudden deafness (2015)","volume":"50","author":"Editorial Board of Chinese Journal of Otorhinolaryngology Head and Neck Surgery; 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