{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T19:20:34Z","timestamp":1777317634730,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T00:00:00Z","timestamp":1670198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005849","name":"Baqiyatallah University of Medical Sciences","doi-asserted-by":"publisher","award":["IRCT20170428174113N23"],"award-info":[{"award-number":["IRCT20170428174113N23"]}],"id":[{"id":"10.13039\/501100005849","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the effect of Neurotec\u00ae herbal capsule (100\u2009mg twice a day for 3\u2009months) on the tinnitus symptoms in comparison with the placebo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>A double\u2010blind randomised clinical trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Otolaryngology clinic of Baqiyatallah Hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Patients suffering from subjective tinnitus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures<\/jats:title>\n                    <jats:p>Pure tone audiometry was measured at .5, 1, 2, 4 and 6\u00a0kHz frequencies before and after the third month of intervention. In addition, Tinnitus Handicap Inventory (THI) questionnaire as well as visual analogue scale (VAS) for tinnitus loudness, daily annoyance, daily life or sleep disturbance, daily perception and mood alteration were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Finally, 103 (69 males and 34 females) patients with a mean age of 51.33\u2009\u00b1\u200913.91\u2009years were analysed. In contrast with control group, patients in intervention group showed a remarkable decrease in THI score after 3\u2009months of treatment (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.05). Although both groups had improvements in VAS scores, mood disturbance, daily tinnitus perception and daily life alteration scores were only improved in the intervention group. The mean pure tone air and bone conduction were not significantly different between the control and the intervention group at baseline and 3\u2009months after the intervention at .5, 1, 2 and 4\u00a0kHz (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u2009.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A 3\u2010month treatment with Neurotec capsules in addition to patient education is of benefit for managing symptoms in patients with chronic tinnitus.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/coa.13989","type":"journal-article","created":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T05:59:58Z","timestamp":1666331998000},"page":"151-157","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Therapeutic effects of\n                    <i>Rosa canina<\/i>\n                    ,\n                    <i>Urtica dioica<\/i>\n                    and\n                    <i>Tanacetum vulgare<\/i>\n                    herbal combination in treatment of tinnitus symptoms: A double\u2010blind randomised clinical trial"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0426-5092","authenticated-orcid":false,"given":"Mohammad Hossein","family":"Khosravi","sequence":"first","affiliation":[{"name":"Department of Research Arka Education and Clinical Research Consultants  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0556-5372","authenticated-orcid":false,"given":"Amirhomayoun","family":"Atefi","sequence":"additional","affiliation":[{"name":"Student Research Committee, School of Medicine Guilan University of Medical Sciences  Rasht Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3993-9053","authenticated-orcid":false,"given":"Afsaneh","family":"Mehri","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Tehran Medical Sciences Islamic Azad University  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5824-3396","authenticated-orcid":false,"given":"Fatemeh","family":"Sodeifian","sequence":"additional","affiliation":[{"name":"Student Research Committee, School of Medicine Shahid Beheshti University of Medical Science  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7668-0813","authenticated-orcid":false,"given":"Jaleh","family":"Yousefi","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Faculty of Medicine Baqiyatallah University of Medical Sciences  Tehran 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