{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T16:06:11Z","timestamp":1792253171119,"version":"4.4.0"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T00:00:00Z","timestamp":1673913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Epithelial\u2013mesenchymal transition (EMT) is an important characteristic in the remodelling of chronic rhinosinusitis with nasal polyps (CRSwNP). IL\u201036\u03b3 and fibroblast activation protein (FAP) may exacerbate remodelling in CRS. Here, we aimed to determine whether IL\u201036\u03b3 and FAP expression are associated with EMT and may be a predictor for CRSwNP prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fifty\u2010two non\u2010Eos CRSwNP patients and 12 control patients were obtained and were followed up for more than 1\u2009year after surgery. IL\u201036\u03b3, FAP and EMT markers expression were evaluated by real\u2010time polymerase chain reaction and western blot. Masson trichrome staining was adopted to assess tissue fibrotic changes. Furthermore, the soluble form of IL\u201036\u03b3 and FAP in nasal secretions was detected by ELISA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>While basal expression of E\u2010cadherin decreased, the expression of IL\u201036\u03b3, vimentin and FAP increased in nasal polyps. In well\u2010prognosis patients, the expression of IL\u201036\u03b3, vimentin and FAP were significantly decreased than in poor\u2010prognosis patients, while the protein expression of E\u2010cadherin was increased. The protein expression of IL\u201036\u03b3 was notably increased in recurrent nasal polyps than in preoperation specimens. A positive relationship between IL\u201036\u03b3 and FAP expression, a negative relationship between IL\u201036\u03b3 and E\u2010cad expression was noted. The soluble form of IL\u201036\u03b3 and FAP increased during the development of non\u2010Eos CRSwNP, with the highest level in poor\u2010prognosis patients after surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Non\u2010Eos CRSwNP have partially undergone EMT under baseline conditions. IL\u201036\u03b3 and FAP expression were related with EMT, the soluble form of IL\u201036\u03b3 and FAP in nasal secretions may predict the prognosis of patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/coa.13993","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T03:24:03Z","timestamp":1665977043000},"page":"347-355","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The role of interleukin 36\u03b3 in the\n                    <scp>epithelial\u2013mesenchymal<\/scp>\n                    transition process of chronic rhinosinusitis: A pilot study"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5884-1345","authenticated-orcid":false,"given":"Li\u2010Fang","family":"Shen","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, The First Affiliated Hospital College of Medicine, Zhejiang University  Hangzhou City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3127-4111","authenticated-orcid":false,"given":"Hai\u2010Hong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, The First Affiliated Hospital College of Medicine, Zhejiang University  Hangzhou City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3541-8282","authenticated-orcid":false,"given":"Yu","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, The First Affiliated Hospital College of Medicine, Zhejiang University  Hangzhou City 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