{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:08:15Z","timestamp":1790680095835,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T00:00:00Z","timestamp":1668384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to evaluate the efficacy of corticosteroid irrigation compared to saline to no nasal irrigation in COVID\u201019 patients with olfactory loss.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and Setting<\/jats:title><jats:p>A randomised controlled study was conducted at the Otolaryngology\u2010Head &amp; Neck Surgery Department, Ramathibodi Hospital, Faculty of Medicine, Mahidol University.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Two hundred thirty\u2010seven COVID\u201019 participants with a new\u2010onset smell loss were recruited into the study. Two hundred twenty\u2010two participants met the inclusion criteria and were randomised into three groups: corticosteroid irrigation, saline irrigation and no treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>The primary outcome was the mean difference in the smell sensation score among the groups after treatment at 1, 2 and 6\u2009weeks. The secondary outcomes measurements included (1) a self\u2010rating quality of life (QOL)\u2010related smell dysfunction score, (2) the change over time in smell sensation score and self\u2010rating QOL\u2010related smell dysfunction score and (3) the median time to complete recovery of smell loss.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean differences in smell sensation scores among the three groups were not statistically significant at any follow\u2010up period. The mean score of self\u2010rating QOL\u2010related smell dysfunction in the corticosteroid group was significantly better than the other groups at 1\u2009week. The change of outcome scores showed significant improvement over time, regardless of the treatments. The median time to complete smell recovery was similar: 3\u2009weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study emphasised that corticosteroid nasal irrigation is not superior to saline or no nasal irrigation in restoring the sense of smell in COVID\u201019\u2010associated olfactory loss.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.14004","type":"journal-article","created":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T05:48:31Z","timestamp":1667800111000},"page":"182-190","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Corticosteroid nasal irrigation as early treatment of olfactory dysfunction in COVID\u201019: A prospective randomised controlled trial"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5715-6028","authenticated-orcid":false,"given":"Jidapa","family":"Tragoonrungsea","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head &amp; Neck Surgery, Faculty of Medicine, Ramathibodi Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1922-5782","authenticated-orcid":false,"given":"Navarat","family":"Tangbumrungtham","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head &amp; Neck Surgery, Faculty of Medicine, Ramathibodi Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9847-4153","authenticated-orcid":false,"given":"Tuleeya","family":"Nitivanichsakul","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head &amp; Neck Surgery, Faculty of Medicine, Ramathibodi Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3682-5130","authenticated-orcid":false,"given":"Boonsam","family":"Roongpuvapaht","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head &amp; Neck Surgery, Faculty of Medicine, Ramathibodi Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7105-9155","authenticated-orcid":false,"given":"Kangsadarn","family":"Tanjararak","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head &amp; Neck Surgery, Faculty of Medicine, Ramathibodi Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,14]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01948-2020"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abc5801"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.0c00249"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otot.2022.04.010"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2021.103033"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2020.102884"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.107871"},{"issue":"1","key":"e_1_2_13_9_1","first-page":"21","article-title":"Efficacy of corticosteroid therapy in the treatment of long\u2010lasting olfactory disorders in COVID\u201019 patients","volume":"59","author":"Vaira LA","year":"2021","journal-title":"Rhinology"},{"key":"e_1_2_13_10_1","first-page":"1","article-title":"Comparison of the healing effect of nasal saline irrigation with triamcinolone acetonide versus nasal saline irrigation alone in COVID\u201019 related olfactory dysfunction: a randomized controlled study","volume":"73","author":"Yildiz E","year":"2021","journal-title":"Indian J Otolaryngol Head Neck Surg"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2020.05.017"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21096"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599820943550"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.708510"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-020-06520-8"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000004093"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2020.173556"},{"key":"e_1_2_13_18_1","unstructured":"ENT UK.Loss of sense of smell as marker of COVID\u201019 infection.2020. 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