{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:31:31Z","timestamp":1790116291047,"version":"4.0.1"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA2014"],"award-info":[{"award-number":["P30 CA2014"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","award":["R01 RR021746"],"award-info":[{"award-number":["R01 RR021746"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although it has been postulated that tobacco use, as well as other environmental exposures, may contribute to chronic rhinosinusitis (CRS), the data remain limited. Here, we utilised a large state population database to assess the association between tobacco use and CRS prevalence among patients undergoing endoscopic sinus surgery (ESS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Employing a case\u2013control study design, the Utah Population Database was queried for patients age &gt;18 with a diagnosis of CRS and tobacco use who underwent ESS between 1996 and 2018. Smoking status was compared between patients with CRS (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a034\u2009350) and random population controls matched 5:1 on sex, birth year, birthplace, time residing in Utah, and pedigree (i.e., familial) information (n\u00a0=\u00a0166\u2009020). Conditional logistic regression models were used for comparisons between CRS patients and their matched controls. All analyses were repeated, additionally adjusting for race, ethnicity, tobacco use, asthma history, and interaction between tobacco use and asthma history.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 200\u2009370 patients were included in the final analysis. Patients with CRS were significantly more likely to demonstrate a history of tobacco use than controls (19.6% vs. 15.0%;\n                      <jats:italic>p\u2009&lt;<\/jats:italic>\n                      \u00a0.001), with an adjusted odds ratio (aOR) of 1.42, 95% confidence interval 1.37\u20131.47;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001. More patients with CRS and comorbid asthma used tobacco (19.5%) than controls with asthma (15.0%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>History of tobacco use may portend increased risk for the development of CRS among patients undergoing ESS compared to healthy controls.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/coa.14013","type":"journal-article","created":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T00:44:30Z","timestamp":1670028270000},"page":"414-422","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Tobacco use increases the risk of chronic rhinosinusitis among patients undergoing endoscopic sinus surgery"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6776-0712","authenticated-orcid":false,"given":"Amarbir S.","family":"Gill","sequence":"first","affiliation":[{"name":"Division of Otolaryngology\u2013Head and Neck Surgery, Department of Surgery University of Utah  Salt Lake City Utah USA"},{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huong","family":"Meeks","sequence":"additional","affiliation":[{"name":"Pedigree and Population Resource, Huntsman Cancer Institute University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Curtin","sequence":"additional","affiliation":[{"name":"Pedigree and Population Resource, Huntsman Cancer Institute University of Utah  Salt Lake City Utah USA"},{"name":"Department of Internal Medicine University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerry","family":"Kelly","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering University of Utah  Salt Lake City Utah USA"},{"name":"Utah Center for Nanomedicine, Nano Institute of Utah University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremiah A.","family":"Alt","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2013Head and Neck Surgery, Department of Surgery University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,11]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/00034894041130S502"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(95)70152-4"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/00034894041130S503"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02646.x"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.22074"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2015.3142"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21553"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12577"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2020.4354"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-018-0823-y"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-8603-9_2"},{"key":"e_1_2_12_13_1","unstructured":"Centers for Disease Control and Prevention.Extinguishing the Tobacco Epidemic in Utah. Office on Smoking and Health National Center for Chronic Disease Prevention and Health Promotion.2021. Available from:https:\/\/www.cdc.gov\/tobacco\/about\/osh\/state-fact-sheets\/utah\/"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/17476348.2020.1812388"},{"key":"e_1_2_12_15_1","unstructured":"Huntsman Cancer Institute.Utah Population Database. Available from:https:\/\/uofuhealth.utah.edu\/huntsman\/utah-population-database\/"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22264"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21469"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.51964\/hlcs10916"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22741"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00168498"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.126.8.940"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599818757697"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhino12.000"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599815572097"},{"key":"e_1_2_12_25_1","unstructured":"Centers for Disease Control and Prevention.Smokeless Tobacco Product Use in the United States. Office on Smoking and Health.2021. Available from:https:\/\/www.cdc.gov\/tobacco\/data_statistics\/fact_sheets\/smokeless\/use_us\/index.htm#adult-national"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/amiajnl-2012-001557"}],"container-title":["Clinical Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/coa.14013","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/coa.14013","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/coa.14013","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T17:16:49Z","timestamp":1692638209000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/coa.14013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,11]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1111\/coa.14013"],"URL":"https:\/\/doi.org\/10.1111\/coa.14013","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/COA.14013\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.14013\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.14013\/v2\/decision1","asserted-by":"object"}]},"ISSN":["1749-4478","1749-4486"],"issn-type":[{"value":"1749-4478","type":"print"},{"value":"1749-4486","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,11]]},"assertion":[{"value":"2022-08-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}