{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T05:40:43Z","timestamp":1772257243882,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T00:00:00Z","timestamp":1672272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Customised acoustic therapy aims to moderate the neural pathways implicated in the pathophysiology of tinnitus. This study aimed to assess the efficacy of customised acoustic therapy administered via a web\u2010based treatment platform.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Clinical trial with prospective recruitment. Fifty\u2010eight participants underwent 6\u2009weeks of customised acoustic therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Treatment was delivered for 2\u00a0h each day using a smartphone, tablet or computer. Treatment was integrated into usual daily activities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Participants with subjective tinnitus were recruited through public and private otolaryngology clinics and electronic and print media.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcomes Measured<\/jats:title>\n                    <jats:p>\n                      <jats:italic>FiveQ<\/jats:italic>\n                      , a novel 5 question tinnitus questionnaire, was measured at baseline and each week of treatment. Statistical analyses, including Wilcoxon, Mann\u2013Whitney and mixed linear regression, were used to assess treatment efficacy and identify factors associated with treatment response.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      39\/58 participants (67.2%) had an improvement in symptom severity scores, 4 had no change (6.9%) and 15 had a decline from baseline (25.9%). Mean\n                      <jats:italic>FiveQ<\/jats:italic>\n                      scores improved by 22.9% from 40.8 (SD\u00a0=\u00a021.4) at baseline to 31.5 (SD\u00a0=\u00a021.3) following 6\u2009weeks of treatment (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). With the exception of the slight tinnitus group, all other groups (from mild to catastrophic) demonstrated a treatment response. Participants with low frequency tinnitus (&lt;2000\u2009Hz) had a significantly greater treatment response (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Customised acoustic therapy administered via a web\u2010based platform demonstrated encouraging efficacy. At least mild symptoms at baseline and low frequency tinnitus were associated with a greater treatment response. Customised acoustic therapy offers accessible and efficacious tinnitus treatment, however longer term clinical studies are required to confirm the observed initial benefit is maintained.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/coa.14027","type":"journal-article","created":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T00:50:32Z","timestamp":1671756632000},"page":"226-234","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Customised acoustic therapy delivered through a web\u2010based platform\u2014An innovative approach to tinnitus treatment"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3081-5433","authenticated-orcid":false,"given":"James Thomas","family":"Connell","sequence":"first","affiliation":[{"name":"Faculty of Health and Medical Sciences University of Adelaide  Adelaide South Australia Australia"},{"name":"Department of Otolaryngology, Head and Neck Surgery Royal Adelaide Hospital  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5545-0194","authenticated-orcid":false,"given":"Ahmed","family":"Bassiouni","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences University of Adelaide  Adelaide South Australia Australia"},{"name":"Department of Otolaryngology, Head and Neck Surgery Royal Adelaide Hospital  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3098-2773","authenticated-orcid":false,"given":"Ella","family":"Harrison","sequence":"additional","affiliation":[{"name":"College of Medicine and Public Health Flinders University  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Laden","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences University of Adelaide  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sinead","family":"O'Brien","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences University of Adelaide  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raguwinder","family":"Sahota","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Royal Adelaide Hospital  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7507-7983","authenticated-orcid":false,"given":"A. Simon","family":"Carney","sequence":"additional","affiliation":[{"name":"College of Medicine and Public Health Flinders University  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6560-6391","authenticated-orcid":false,"given":"Andrew","family":"Foreman","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences University of Adelaide  Adelaide South Australia Australia"},{"name":"Department of Otolaryngology, Head and Neck Surgery Royal Adelaide Hospital  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suren","family":"Krishnan","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences University of Adelaide  Adelaide South Australia Australia"},{"name":"Department of Otolaryngology, Head and Neck Surgery Royal Adelaide Hospital  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John\u2010Charles","family":"Hodge","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Royal Adelaide Hospital  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,12,29]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599814547475"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2018.00288"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2017.00036"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1084713808319941"},{"key":"e_1_2_12_6_1","unstructured":"Annual Benefits Report Fiscal Year 2020. 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