{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T04:14:29Z","timestamp":1784693669048,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T00:00:00Z","timestamp":1675296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      Granular myringitis (GM) is a troublesome disease with a high incidence of recurrence and relapse. CO\n                      <jats:sub>2<\/jats:sub>\n                      laser vaporisation and trichloroacetic acid (TAA) have been applied in treating several otological diseases, both with favourable therapeutic efficacy. However, long\u2010term therapeutic efficacy of both CO\n                      <jats:sub>2<\/jats:sub>\n                      laser vaporisation and TAA cauterisation against GM has not yet been evaluated. We aimed to investigate the therapeutic potential of CO\n                      <jats:sub>2<\/jats:sub>\n                      laser vaporisation and TAA cauterisation in GM management.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Prospective and randomised study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>\n                      A total of 88 GM patients who failed therapy with boric acid, alcohol and glycerin ear drop otic solution between July 2009 and January 2018 were included. Participants were randomly assigned to receive CO\n                      <jats:sub>2<\/jats:sub>\n                      laser vaporisation (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a039) or TAA cauterisation (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a049).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures<\/jats:title>\n                    <jats:p>Main outcomes were treatment success, complications after 4\u00a0months of treatment, and recurrence within 4\u201312\u2009months after treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The success rate was significantly higher in the CO\n                      <jats:sub>2<\/jats:sub>\n                      group than in the TAA group (94.9% vs. 77.6%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.023). After 4\u00a0months of treatment, the GM recurrence rate was comparable between the two groups (13.5% vs. 18.4%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.562). The CO\n                      <jats:sub>2<\/jats:sub>\n                      laser group had one case of perforation and one case of severe vertigo, whereas one participant in the TAA cauterisation group experienced hearing loss.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Both TAA cauterisation and CO\n                      <jats:sub>2<\/jats:sub>\n                      laser vaporisation are safe and effective treatments for GM. The success rate of CO\n                      <jats:sub>2<\/jats:sub>\n                      laser vaporisation for treating GM is higher than that of TAA cauterisation. Recurrence rates are comparable within 1\u00a0year.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/coa.14039","type":"journal-article","created":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T06:43:23Z","timestamp":1673851403000},"page":"451-456","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Efficacy of carbon dioxide laser and caustic agent cauterisation for the focal granular myringitis: A randomised trial"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2348-3055","authenticated-orcid":false,"given":"Yu\u2010Xiang","family":"Kuo","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Shin\u2010Kong Wu Ho\u2010Su Memorial Hospital  Taipei 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