{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T13:58:53Z","timestamp":1788789533153,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T00:00:00Z","timestamp":1680480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Tracheoesophageal puncture (TEP) is considered the gold standard for voice rehabilitation after total laryngectomy. One of the main causes of treatment failure, and a potentially serious complication, is the TEP enlargement and\/or leakage around the voice prosthesis. The injection of biocompatible material to increase the volume of the puncture surrounding tissue has been studied as a popular option for conservative treatment of enlarged tracheoesophageal fistula. The aim of this paper was to perform a systematic review of the efficacy and safety of such treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Desingn<\/jats:title>\n                    <jats:p>Search conducted in PubMed\/MEDLINE, the Cochrane Library, Google Scholar, Scielo and Web of Science and through the meta\u2010searcher Trip Database based on Preferred Reporting Items for a Systematic Review and Meta\u2010analysis (PRISMA) statement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Settings<\/jats:title>\n                    <jats:p>Human experiments published in peer\u2010reviewed journals, where investigators assessed the use of peri\u2010fistular tissue augmentation for periprosthetic leakage were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Laryngectomized patients with voice prosthesis, presenting periprosthetik leak due to enlarged fistula.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main outcomes measures<\/jats:title>\n                    <jats:p>mean\u2010duration without new leak.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 196 peri\u2010fistular tissue augmentation procedures in 97 patients were found in the 15 selected articles. The 58.8% of patients had a time without periprosthetic leak after treatment of &gt;6\u00a0months. The 88.7% of tissue augmentation treatments resulted in periprosthetic leakage cessation. The general level of evidence of the studies included in this review was low.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Tissue augmentation treatment is a minimally invasive, biocompatible and safe solution that temporarily resolves periprosthetic leaks in many cases. There is no standard technique or material, and treatment needs to be individualised according to the experience of the practitioner and the characteristics of the patient. Future randomised studies are needed to confirm these results.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/coa.14052","type":"journal-article","created":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T23:09:13Z","timestamp":1680563353000},"page":"515-526","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Tissue augmentation treatment for periprosthetic leakage in patients who have undergone a total laryngectomy: A systematic review"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1829-6597","authenticated-orcid":false,"given":"Miguel","family":"Mayo\u2010Y\u00e1\u00f1ez","sequence":"first","affiliation":[{"name":"Otorhinolaryngology\u2014Head and Neck Surgery Department Complexo Hospitalario Universitario A Coru\u00f1a (CHUAC)  15006 A Coru\u00f1a Galicia Spain"},{"name":"Clinical Research in Medicine, International Center for Doctorate and Advanced Studies (CIEDUS) Universidade de Santiago de Compostela (USC)  15782 Santiago de Compostela Galicia Spain"},{"name":"Young\u2010Otolaryngologists of the International Federations of Oto\u2010Rhino\u2010Laryngological Societies (YO\u2010IFOS) Study Group  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes D\u00edaz","family":"Ramos\u2010Neble","sequence":"additional","affiliation":[{"name":"School of Medicine Universidade de Santiago de Compostela (USC)  15782 Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irma","family":"Cabo\u2010Varela","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology\u2014Head and Neck Surgery Department Complexo Hospitalario Universitario A Coru\u00f1a (CHUAC)  15006 A Coru\u00f1a Galicia Spain"},{"name":"Health Sciences Programme, International Center for Doctorate (EIDUDC) Universidade da Coru\u00f1a (UDC)  Coru\u00f1a Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9454-9464","authenticated-orcid":false,"given":"Carlos Miguel","family":"Chiesa\u2010Estomba","sequence":"additional","affiliation":[{"name":"Young\u2010Otolaryngologists of the International Federations of Oto\u2010Rhino\u2010Laryngological Societies (YO\u2010IFOS) Study Group  Paris France"},{"name":"Otorhinolaryngology\u2014Head and Neck Surgery Department Hospital Universitario Donostia\u2014Biodonostia Research Institute  20014 Donostia Gipuzkoa Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0845-0845","authenticated-orcid":false,"given":"J\u00e9r\u00f4me R.","family":"Lechien","sequence":"additional","affiliation":[{"name":"Young\u2010Otolaryngologists of the International Federations of Oto\u2010Rhino\u2010Laryngological Societies (YO\u2010IFOS) Study Group  Paris France"},{"name":"Department of Otolaryngology Polyclinique de Poitiers, Elsan Hospital  Poitiers France"},{"name":"Department of Otolaryngology\u2014Head &amp; Neck Surgery, Foch Hospital, School of Medicine, UFR Simone Veil Universit\u00e9 Versailles Saint\u2010Quentin\u2010en\u2010Yvelines (Paris Saclay University)  Paris France"},{"name":"Department of Human Anatomy and Experimental Oncology, UMONS Research Institute for Health Sciences and Technology University of Mons (UMons)  Mons Belgium"},{"name":"Department of Otolaryngology\u2014Head &amp; Neck Surgery CHU Saint\u2010Pierre (CHU de Bruxelles)  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7070-0780","authenticated-orcid":false,"given":"Nicolas","family":"Fakhry","sequence":"additional","affiliation":[{"name":"Young\u2010Otolaryngologists of the International Federations of Oto\u2010Rhino\u2010Laryngological Societies (YO\u2010IFOS) Study Group  Paris France"},{"name":"Department of Oto\u2010Rhino\u2010Laryngology Head and Neck Surgery La Conception University Hospital, AP\u2010HM, Aix Marseille Univ  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1251-0185","authenticated-orcid":false,"given":"Antonino","family":"Maniaci","sequence":"additional","affiliation":[{"name":"Young\u2010Otolaryngologists of the International Federations of Oto\u2010Rhino\u2010Laryngological Societies (YO\u2010IFOS) Study Group  Paris France"},{"name":"Department of Medical and Surgical Sciences and Advanced Technologies \u2018GF Ingrassia,\u2019 ENT Section University of Catania  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3710-5706","authenticated-orcid":false,"given":"Katherine A.","family":"Hutcheson","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, Division of Radiation Oncology The University of Texas, M. 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