{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T06:09:10Z","timestamp":1759385350616,"version":"3.40.5"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T00:00:00Z","timestamp":1682985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004330","name":"GSK","doi-asserted-by":"publisher","award":["213951"],"award-info":[{"award-number":["213951"]}],"id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To characterise the real\u2010world burden of chronic rhinosinusitis with nasal polyps (CRSwNP) in the UK, stratified by number of surgeries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>UK Clinical Practice Research Datalink Aurum database with Hospital Episodes Statistics linkage (2007\u20132019).<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Adults \u226518\u2009years of age with a first NP diagnosis (index) and 365\u2009days of baseline and \u2265180\u2009days of follow\u2010up data. Follow\u2010up continued until disenrollment, death or end of data collection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>Primary: primary care physician prescribed CRSwNP\u2010related treatments, and all\u2010cause healthcare resource utilisation (HCRU) in 90\u2009days post\u2010index, stratified by surgeries during follow\u2010up. Secondary: rate of surgery and CRSwNP point prevalence. Baseline patient demographics, clinical characteristics and comorbidities were also assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 33\u2009107 patients included, 23.5% and 2.2% had \u22651 and \u22652 surgeries during follow\u2010up, respectively (mean follow\u2010up: 5.3\u2009years). Patients with more surgeries (\u22652\/\u22651\/0) during follow\u2010up were more likely to be male (67.3%\/69.0%\/58.0%), have asthma (37.8%\/28.2%\/20.2%) and have baseline blood eosinophil counts \u2265300 cells\/\u03bcL (68.5%\/66.0%\/51.5%). During the first 90\u2010days post\u2010index as surgery number increased, the proportion of patients using oral corticosteroids (25.8%\/20.7%\/14.2%) and mean (SD) number of all\u2010cause healthcare visits (5.9 [4.2]\/5.4 [4.0]\/4.9 [4.2]) increased. Time between surgeries was shorter among patients with more surgeries. CRSwNP prevalence on 31 December 2018 was 476 cases per 100\u2009000 persons.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A small proportion of patients in the UK required multiple surgeries for CRSwNP and this was associated with increasing comorbidity burden, baseline blood eosinophil counts, CRSwNP\u2010related treatment and HCRU use.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.14070","type":"journal-article","created":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T11:50:24Z","timestamp":1683028224000},"page":"680-688","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Real\u2010world characterisation of patients with chronic rhinosinusitis with nasal polyps with and without surgery in England"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3775-1401","authenticated-orcid":false,"given":"Victoria 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