{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T08:54:47Z","timestamp":1768899287303,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T00:00:00Z","timestamp":1684713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare post\u2010treatment neck and shoulder function between human papillomavirus\u2010associated oropharynx squamous cell carcinoma (HPV\u2009+\u2009OPSCC) treatments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective, repeated\u2010measures study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Tertiary care center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Treatment\u2010na\u00efve patients with American Joint Committee on Cancer eighth edition stage T0\u20103\/N0\u20102 HPV+OPSCC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>Patients completed the Neck Dissection Impairment Index (NDII) pre\u2010treatment and 3\u2010months and 1\u2010year post\u2010treatment. The NDII assesses 10 neck and shoulder functions scored 0\u20135 (total score 0\u2013100), with higher scores suggesting better function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 106 patients underwent: surgery alone (SA, <jats:italic>n<\/jats:italic>\u2009=\u200946, 43%), surgery with adjuvant radiation\u2009\u00b1\u2009chemotherapy (S\u2009+\u2009a[C]XRT, <jats:italic>n<\/jats:italic>\u2009=\u200918, 17%), or definitive radiation\u2009\u00b1\u2009chemotherapy (d[C]XRT, <jats:italic>n<\/jats:italic>\u2009=\u200942, 40%). cTN classification and pre\u2010treatment NDII scores did not differ between groups. SA patients reported worsened 3\u2010month post\u2010treatment versus pre\u2010treatment self\u2010care (4.6 vs. 5.0), lifting light (4.6 vs. 5.0) and heavy (4.2 vs. 4.8) objects, overhead reach (4.5 vs. 4.9), activity (4.5 vs. 4.9), socialization (4.7 vs. 4.9), recreation (4.6 vs. 4.9), and overall score (86.8 vs. 95.3) (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). One\u2010year post\u2010treatment scores (<jats:italic>n<\/jats:italic>\u2009=\u200934) were no different than pre\u2010treatment in all domains. S\u2009+\u2009a[C]XRT patients reported worsened 3\u2010month versus pre\u2010treatment stiffness (4.0 vs. 4.8), lifting heavy objects (3.8 vs. 4.9), overhead reach (4.2 vs. 4.9), socialization (4.6 vs. 5.0), recreation (4.4 vs. 4.9) and overall score (82.4 vs. 96.0) (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). One\u2010year post\u2010treatment scores (<jats:italic>n<\/jats:italic>\u2009=\u200913) were no different than pre\u2010treatment in all domains. d[C]XRT patients reported worsened 3\u2010month versus pre\u2010treatment difficulty lifting heavy objects (4.3 vs. 4.7) and recreation (4.3 vs. 4.7). One\u2010year posttreatment scores (<jats:italic>n<\/jats:italic>\u2009=\u200921) were no different than pre\u2010treatment in all domains.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>HPV\u2009+\u2009OPSCC patients may experience mild shoulder\/neck dysfunction 3 months after treatment that usually resolves by 1\u2009year, independent of treatment modality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.14076","type":"journal-article","created":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T11:39:36Z","timestamp":1684755576000},"page":"756-765","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A prospective evaluation of neck and shoulder function following treatments of <scp>early\u2010stage<\/scp> human <scp>papillomavirus\u2010associated<\/scp> oropharynx cancer"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8060-2954","authenticated-orcid":false,"given":"Arushi","family":"Gulati","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of California  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8429-5779","authenticated-orcid":false,"given":"Karolina","family":"Plonowska\u2010Hirschfeld","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of California  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1272-9208","authenticated-orcid":false,"given":"Erika M.","family":"Stephens","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of California  San Francisco California 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