{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T04:43:15Z","timestamp":1788410595012,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T00:00:00Z","timestamp":1693353600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS\u20102023\u201000209494"],"award-info":[{"award-number":["RS\u20102023\u201000209494"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2022R1F1A1066232"],"award-info":[{"award-number":["2022R1F1A1066232"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2019M3E5D5064110"],"award-info":[{"award-number":["2019M3E5D5064110"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the association between statin use and chronic rhinosinusitis (CRS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and Setting<\/jats:title><jats:p>Systematic review and meta\u2010analysis. The methodological quality of studies was assessed using the Newcastle\u2013Ottawa scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Patients with CRS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>Pooled odds ratios (ORs) with 95% confidence interval (CIs) in analyses of studies that compared the prevalence of CRS, nasal polyp, difference of Lund\u2010Kennedy endoscopic score, Lund\u2010Mackay CT score and Sino\u2010nasal Outcome Test\u201022.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The analysis included eight studies and 445\u2009465 patients. Patients who used statins were at lower risk for CRS than those who did not (OR\u2009=\u20090.7457, 95% CI\u2009=\u20090.6629\u20130.8388, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.0%). Patients with hyperlipidaemia were at higher risk for CRS than those with normal serum levels of lipid (OR\u2009=\u20091.3590, 95% CI\u2009=\u20091.2831\u20131.4394, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200933.3%). However, there were no significant differences in the risk for nasal polyps between CRS patients using statins or not (OR\u2009=\u20091.0931, 95% CI\u2009=\u20090.7860\u20131.5202, <jats:italic>p<\/jats:italic>\u2009=\u20090.5968, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.0%). Additionally, statin use was not related to Lund\u2010Kennedy endoscopic scores, Lund\u2010Mackay CT scores or sino\u2010nasal outcome test\u201022 scores in CRS patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The risk for CRS is lower in patients who use statins and those without hyperlipidaemia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.14096","type":"journal-article","created":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T00:54:52Z","timestamp":1693443292000},"page":"820-827","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Are statins effective in preventing chronic rhinosinusitis? A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9248-5572","authenticated-orcid":false,"given":"Do Hyun","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Seoul Saint Mary's Hospital, College of Medicine, The Catholic University of Korea  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8981-2536","authenticated-orcid":false,"given":"Sung Won","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Seoul Saint Mary's Hospital, College of Medicine, The Catholic University of Korea  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7728-1232","authenticated-orcid":false,"given":"Jae Sang","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Seoul Saint Mary's Hospital, College of Medicine, The Catholic University of Korea  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5032-5853","authenticated-orcid":false,"given":"Geun\u2010Jeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Seoul Saint Mary's Hospital, College of Medicine, The Catholic University of Korea  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6214-3881","authenticated-orcid":false,"given":"Mohammed Abdullah","family":"Basurrah","sequence":"additional","affiliation":[{"name":"Department of Surgery College of Medicine, Taif University  Taif Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8736-7558","authenticated-orcid":false,"given":"Sun Hong","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Seoul Saint Mary's Hospital, College of Medicine, The Catholic University of Korea  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2838-7820","authenticated-orcid":false,"given":"Se Hwan","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Seoul Saint Mary's Hospital, College of Medicine, The Catholic University of Korea  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,30]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22741"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2022.01.016"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.28085"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin20.401"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25180"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1839"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2006.11.027"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.5.2903"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599811400367"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.23075"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.29219"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.3342\/kjorl-hns.2015.58.1.25"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.21053\/ceo.2022.00780"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22880"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11010026"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02877780"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.21053\/ceo.2022.01718"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.18787\/jr.2022.00407"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.21053\/ceo.2022.00052"},{"key":"e_1_2_13_22_1","doi-asserted-by":"crossref","unstructured":"KimDH KimSW HanJS KimGJ.The prognostic utilities of various risk factors for laryngeal squamous cell carcinoma: a systematic review and meta\u2010analysis. 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