{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T22:14:55Z","timestamp":1783721695822,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T00:00:00Z","timestamp":1695772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["110\u20102314\u2010B\u2010182A\u2010124\u2010MY3"],"award-info":[{"award-number":["110\u20102314\u2010B\u2010182A\u2010124\u2010MY3"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Minimally invasive, single\u2010staged multilevel surgery (MISS MLS) could be an optimal treatment for selected patients with obstructive sleep apnea (OSA). We aim to systematically review the efficacy of MISS MLS for patients with OSA, as well as the clinical outcomes and possible complications in OSA patients before and after MISS MLS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and setting<\/jats:title><jats:p>Systematic review and meta\u2010analysis. Six databases were searched, and the PRISMA guideline was followed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Patients with OSA receiving MISS MLS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>The random\u2010effects model was adopted for the statistical synthesis. The percentage and 95% confidence interval (CI) were adopted as the effect measurements of MISS MLS for OSA. Subgroup analyses and sensitivity analyses were also performed to identify the heterogeneity among the studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were initially 154 articles for identification. Eventually, six studies with a total of 848 OSA patients completely met the inclusion criteria and were further enrolled for analysis. The pooled analysis showed statistically significant lower AHI (apnea\/hypopnea index, \/hr.; mean difference: \u22128.931, 95% CI: \u221211.591 to \u22126.271, I<jats:sup>2<\/jats:sup>\u2009=\u200987.4%), ESS (mean difference: \u22122.947, 95% CI: \u22124.465 to \u22121.429, I<jats:sup>2<\/jats:sup>\u2009=\u200994.9%), and snoring severity with 0\u201010 visual analog scale after surgery (mean difference: \u22124.966, 95% CI: \u22125.804 to \u22124.128, I<jats:sup>2<\/jats:sup>\u2009=\u200996.4%). The success rate was 46% in mild\/moderate OSA; however, 18% in severe OSA. There were no major complications occurred.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The acceptable surgical outcomes, esp. in mild\/moderate OSA, and rare complications are the major advantages of MISS MLS. The evidence of this study could aid the decision making in selecting suitable treatment programs for OSA patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.14098","type":"journal-article","created":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T13:00:26Z","timestamp":1695819626000},"page":"828-840","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Minimally invasive, single\u2010stage, multilevel surgery for obstructive sleep apnoea: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"48","author":[{"given":"Sara","family":"Rahavi\u2010Ezabadi","sequence":"first","affiliation":[{"name":"Otorhinolaryngology Research Center, Otorhinolaryngology Head and Neck Surgery Department Children's Medical Center, Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan\u2010Ye","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Kaohsiung Chang Gung Memorial Hospital  Kaohsiung Taiwan"},{"name":"Sleep Center and Robotic Surgery Center Kaohsiung Chang Gung Memorial Hospital  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Han","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Medicine, College of Medicine Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung\u2010Wei","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Kaohsiung Chang Gung Memorial Hospital  Kaohsiung Taiwan"},{"name":"Department of Education Kaohsiung Chang Gung Memorial Hospital  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun\u2010Tuan","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Business Management, Institute of Healthcare Management, Institute of Biomedical Sciences National Sun Yat\u2010sen University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Friedman","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Division of Sleep Surgery Rush University Medical Center  Chicago Illinois USA"},{"name":"Department of Otolaryngology, Advanced Center for Specialty Care Advocate Illinois Masonic Medical Center  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna M.","family":"Salapatas","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Advanced Center for Specialty Care Advocate Illinois Masonic Medical Center  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amin","family":"Amali","sequence":"additional","affiliation":[{"name":"Sleep Breathing Disorders Research Center (SBDRC), Occupational Sleep Research Center (OSRC), Otorhinolaryngology Research Center, Otorhinolaryngology Head and Neck Surgery Department Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8822-0619","authenticated-orcid":false,"given":"Hsin\u2010Ching","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Kaohsiung Chang Gung Memorial Hospital  Kaohsiung Taiwan"},{"name":"Sleep Center and Robotic Surgery Center Kaohsiung Chang Gung Memorial Hospital  Kaohsiung Taiwan"},{"name":"Department of Business Management, Institute of Healthcare Management, Institute of Biomedical Sciences National Sun Yat\u2010sen University  Kaohsiung Taiwan"},{"name":"Center for Quality Management Kaohsiung Chang Gung Memorial Hospital Kaohsiung; 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