{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T01:00:45Z","timestamp":1792458045750,"version":"4.5.0"},"reference-count":55,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T00:00:00Z","timestamp":1696982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Ototoxicity is a common disabling side effect of platinum\u2010based chemotherapy. This study aimed to assess the evidence on the management of platinum\u2010induced ototoxicity in adult cancer patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Four databases were searched up to 1 November 2022. Original studies were included if they reported on a pharmacologic or non\u2010pharmacologic intervention to prevent or treat platinum ototoxicity in adults. The articles' quality was assessed via two grading scales.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Nineteen randomised controlled trials and five quasi\u2010experimental studies with 1673 patients were analysed. Eleven interventions were identified, nine pharmacological and two non\u2010pharmacological. Six of the interventions (sodium thiosulphate, corticoids, sertraline, statins, multivitamins and D\u2010methionine) showed mild benefits in preventing cisplatin\u2010induced ototoxicity. Only one trial assessed corticoids as a potential treatment. Overall, only six trials were deemed with a low risk of bias. The majority of studies inadequately documented intervention\u2010related adverse effects, thereby limiting safety conclusions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Current interventions have mild benefits in preventing cisplatin\u2010induced ototoxicity in adult cancer patients. Sodium thiosulphate is the most promising intervention as a preventive strategy. Rigorous, high\u2010quality research is warranted, encompassing an evaluation of all potential symptoms and innovative treatment modalities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/coa.14106","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T01:23:34Z","timestamp":1697073814000},"page":"1-15","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Prevention and treatment of cisplatin\u2010induced ototoxicity in adults: A systematic review"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7071-0516","authenticated-orcid":false,"given":"Juan Esteban","family":"Correa\u2010Morales","sequence":"first","affiliation":[{"name":"Palliative Care Program Universidad de La Sabana  Bogot\u00e1 Colombia"},{"name":"Instituto Nacional de Cancerolog\u00eda  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Giraldo\u2010Moreno","sequence":"additional","affiliation":[{"name":"Universidad CES  Medell\u00edn Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nidia","family":"Mantilla\u2010Manosalva","sequence":"additional","affiliation":[{"name":"Palliative Care Program Universidad de La Sabana  Bogot\u00e1 Colombia"},{"name":"Instituto Nacional de Cancerolog\u00eda  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Cuellar\u2010Valencia","sequence":"additional","affiliation":[{"name":"Palliative Care Program Universidad de La Sabana  Bogot\u00e1 Colombia"},{"name":"Instituto Nacional de Cancerolog\u00eda  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar Felipe","family":"Borja\u2010Montes","sequence":"additional","affiliation":[{"name":"University New Mexico  Albuquerque New Mexico USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lennis Jazmin","family":"Bedoya\u2010Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Palliative Care Program Universidad de La Sabana  Bogot\u00e1 Colombia"},{"name":"Instituto Nacional de Cancerolog\u00eda  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Fernanda","family":"Iriarte\u2010Aristiz\u00e1bal","sequence":"additional","affiliation":[{"name":"Palliative Care Program Universidad de La Sabana  Bogot\u00e1 Colombia"},{"name":"Instituto Nacional de Cancerolog\u00eda  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias","family":"Quintero\u2010Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Palliative Care Program Universidad de La Sabana  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Marcela","family":"Zuluaga\u2010Liberato","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Cancerolog\u00eda  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,11]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2022.102203"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.66.8822"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-014-3283-0"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-18-3179"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2006.12.017"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2021.108204"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.25112"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2018.02.021"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2019.08.002"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2021.03.008"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01837-1"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-016-4117-z"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2019.3550"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/AUD.0000000000001172"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(19)30336-0"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/SPC.0000000000000505"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11764-017-0662-8"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_2_13_20_1","unstructured":"WellsGA SheaB O'ConnellD PetersonJ WelchV LososM et al.The Newcastle\u2010Ottawa Scale (NOS) for assessing the quality if nonrandomized studies in meta\u2010analyses. 2023.https:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.htm"},{"key":"e_1_2_13_21_1","unstructured":"PopayJ RobertsHM SowdenAJ PetticrewM AraiL RodgersM et al.Guidance on the conduct of narrative synthesis in systematic reviews a product from the ESRC methods Programme. ESRC Methods Programme.2006;1(1):5\u20139."},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1995.13.2.490"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1995.13.5.1231"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1996.14.7.2101"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1997.01900090094014"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008353505916"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200409000-00030"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.08.9540"},{"issue":"4","key":"e_1_2_13_29_1","first-page":"173","article-title":"Preventing cisplatin induced ototoxicity by N\u2010acetylcysteine and salicylate","volume":"20","author":"Y\u0131ld\u0131r\u0131m M","year":"2010","journal-title":"Kulak Burun Bogaz Ihtis Derg"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0b013e31822e006d"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24360"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599814524894"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489.2015.1035797"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2017.09.033"},{"issue":"3","key":"e_1_2_13_35_1","first-page":"261","article-title":"Treatment of cisplatin\u2010induced ototoxicity by intra\u2010tympanic corticosteroid injection","volume":"23","author":"Nasr WF","year":"2018","journal-title":"Indian J Otol"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.5935\/0946-5448.20180029"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40463-019-0327-x"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000003069"},{"key":"e_1_2_13_39_1","first-page":"327","article-title":"Protective role of N\u2010acetylcisteine from cisplatin\u2010induced ototoxicity in patients with head and neck cancer. A randomized, placebo controlled clinical trial","volume":"81","author":"Mu\u00f1oz D","year":"2021","journal-title":"Rev Otorrinolaringol Cir Cabeza Cuello"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI142616"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/AUD.0000000000001209"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2004.02.029"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2017.e00251"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1080\/14992027.2021.1983215"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24396"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.1411"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1080\/17425255.2020.1806235"},{"issue":"5","key":"e_1_2_13_48_1","first-page":"309","article-title":"Meta\u2010analysis of the efficacy of amifostine in the prevention of cisplatin ototoxicity","volume":"41","author":"Duval M","year":"2012","journal-title":"J Otolaryngol Head Neck Surg"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1801109"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.18895"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1590\/2176-9451.19.4.027-029.ebo"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1177\/014556131109000506"},{"key":"e_1_2_13_53_1","unstructured":"Clinicaltrials.gov.Efficacy of sodium thiosulfate and mannitol in reducing ototoxicity in adult patients receiving cisplatin chemotherapy. ClinicalTrials.gov Identifier: NCT05129748.2022[cited 2023 Jan 1] Available from:https:\/\/clinicaltrials.gov\/ct2\/show\/NCT05129748"},{"key":"e_1_2_13_54_1","unstructured":"Clinicaltrials.gov.Evaluation of the effect of rosuvastatin on cisplatin\u2010induced nephrotoxicity and ototoxicity. [1 screen]. ClinicalTrials.gov Identifier: NCT04817904.2022[cited 2023 Jan 1]. Available from:https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04817904"},{"key":"e_1_2_13_55_1","unstructured":"Clinicaltrials.gov.Intratympanic N\u2010Acetylcysteine for prevention of cisplatin\u2010induced ototoxicity. [1 screen]. ClinicalTrials.gov Identifier: NCT04291209.2022[cited 2023 Jan 1]. Available from:https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04291209"},{"key":"e_1_2_13_56_1","unstructured":"Clinicaltrials.gov.Intratympanic administration of N\u2010acetylcysteine for protection of cisplatin\u2010induced ototoxicity. [1 screen]. ClinicalTrials.gov Identifier: NCT04226456.2022[cited 2023 Jan 1]. Available from:https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04226456"}],"container-title":["Clinical Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/coa.14106","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T22:06:31Z","timestamp":1706565991000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/coa.14106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,11]]},"references-count":55,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1111\/coa.14106"],"URL":"https:\/\/doi.org\/10.1111\/coa.14106","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/COA.14106\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.14106\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.14106\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.14106\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.14106\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.14106\/v1\/decision1","asserted-by":"object"}]},"ISSN":["1749-4478","1749-4486"],"issn-type":[{"value":"1749-4478","type":"print"},{"value":"1749-4486","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,11]]},"assertion":[{"value":"2023-02-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}