{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:41:28Z","timestamp":1772160088972,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T00:00:00Z","timestamp":1697587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["111\u20102314\u2010B\u2010002\u2010193\u2010MY3"],"award-info":[{"award-number":["111\u20102314\u2010B\u2010002\u2010193\u2010MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["112\u2010S0226"],"award-info":[{"award-number":["112\u2010S0226"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aims to identify characteristics in image\u2010based computational fluid dynamics (CFD) in children with obstructive sleep apnea (OSA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Diagnostic study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Hospital\u2010based cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Children with symptoms suggestive of OSA were recruited and underwent polysomnography.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main outcome measures<\/jats:title>\n                    <jats:p>Three\u2010dimensional models of computational fluid dynamics were derived from cone\u2010beam computed tomography.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 68 children participated in the study (44 boys; mean age: 7.8\u2009years), including 34 participants having moderate\u2010to\u2010severe OSA (apnea\u2010hypopnea index [AHI] greater than 5 events\/h), and 34 age, gender, and body mass index percentile matched participants having primary snoring (AHI less than 1). Children with moderate\u2010to\u2010severe OSA had a significantly higher total airway pressure (166.3 vs. 39.1\u2009Pa,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.009), total airway resistance (9851 vs. 2060 Newton\u2010metre,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.004) and velocity at a minimal cross\u2010sectional area (65.7 vs. 8.8 metre per second,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.017) than those with primary snoring. The optimal cut\u2010off points for moderate\u2010to\u2010severe OSA were 46.2\u2009Pa in the total airway pressure (area under the curve [AUC]\u2009=\u200973.2%), 2373 Newton\u2010metre in the total airway resistance (AUC\u2009=\u200972.5%) and 12.6\u2009metres per second in the velocity at a minimal cross\u2010sectional area (AUC\u2009=\u200970.5%). The conditional logistic regression model revealed that total airway pressure, total airway resistance and velocity at minimal cross\u2010sectional area were significantly associated with an increased risk of moderate\u2010to\u2010severe OSA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study demonstrates that CFD could be a useful tool for evaluating upper airway patency in children with OSA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/coa.14114","type":"journal-article","created":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T02:48:56Z","timestamp":1697683736000},"page":"109-116","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Computational fluid dynamics study in children with obstructive sleep 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Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hung\u2010Ta","family":"Hsiao","sequence":"additional","affiliation":[{"name":"Soteria Biotech Co., Ltd  New Taipei City 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