{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:41:30Z","timestamp":1772160090076,"version":"3.50.1"},"reference-count":11,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T00:00:00Z","timestamp":1704326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013342","name":"NIHR Imperial Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013342","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Airway reconstruction for laryngo tracheal stenosis (LTS) improves dyspnoea. There is little evidence relating to impact upon voice and swallowing. We explored voice and swallowing outcomes in adults with LTS before and after reconstructive surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Outcome measures were collected pre\u2010reconstructive surgery, two\u2010weeks post\u2010surgery and up to 4\u20106 months post\u2010surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Tertiary referral centre.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>With ethical approval, twenty consecutive adult (\u226518 years) LTS patients undergoing airway reconstruction were prospectively recruited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main outcome measures<\/jats:title>\n                    <jats:p>These included physiological values (maximum phonation time (MPT) and fundamental frequency; penetration aspiration score, residue score), clinician\u2010reported (GRBAS, functional oral intake score, 100ml Water Swallow Test) and patient\u2010reported outcomes (Voice Handicap Index\u201010, Reflux Symptoms Index, Eating Assessment Tool, Dysphagia Handicap Index).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The observational study identified patient\u2010reported and clinician\u2010reported voice and swallow difficulties pre\u2010 and post\u2010surgery; median and interquartile range are reported at each time point: Voice Handicap Index\u201010 23 (8\u201031); 20.5 (9\u201033.5), 24.5 (12.5\u201029); Dysphagia Handicap Index 9 (0\u201037); 13 (7\u201044); 15 (4\u201034); GRBAS grade 1(1\u20102); 2 (1\u20102.5); 2(1\u20102); 100ml Water Swallow Test volume score 16.7 (11.1\u201020); 14.3 (12.5\u201016.7); 16.7 (14.3\u201020.0); 100ml Water Swallow Test capacity score 16.3 \u00b1 9.0; 11.0 \u00b1 4.1; 12.5 \u00b1 2.6.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We present the first prospective data on voice and swallowing outcomes in adults with LTS before and after reconstructive surgery. The variability of the outcomes was higher than expected but importantly, for many the voice and swallow outcomes were not within normal limits before surgery. The clinical value of the study demonstrates the need for individual assessment and management of LTS patients\u2019 voice and swallowing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/coa.14138","type":"journal-article","created":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T18:49:35Z","timestamp":1704394175000},"page":"324-330","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The voice and swallowing profile of adults with laryngotracheal stenosis before and after reconstructive surgery:\n                    <scp>A<\/scp>\n                    prospective, descriptive observational study"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1796-731X","authenticated-orcid":false,"given":"Gemma M.","family":"Clunie","sequence":"first","affiliation":[{"name":"Surgery and Cancer Imperial College London  London UK"},{"name":"Imperial College Healthcare NHS Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4925-3124","authenticated-orcid":false,"given":"Justin W. G.","family":"Roe","sequence":"additional","affiliation":[{"name":"Surgery and Cancer Imperial College London  London UK"},{"name":"Imperial College Healthcare NHS Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5771-5096","authenticated-orcid":false,"given":"Chadwan","family":"Al\u2010Yaghchi","sequence":"additional","affiliation":[{"name":"Imperial College Healthcare NHS Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1816-8939","authenticated-orcid":false,"given":"Caroline M.","family":"Alexander","sequence":"additional","affiliation":[{"name":"Surgery and Cancer Imperial College London  London UK"},{"name":"Imperial College Healthcare NHS Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4672-332X","authenticated-orcid":false,"given":"Alison","family":"McGregor","sequence":"additional","affiliation":[{"name":"Surgery and Cancer Imperial College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gurpreet","family":"Sandhu","sequence":"additional","affiliation":[{"name":"Surgery and Cancer Imperial College London  London UK"},{"name":"Imperial College Healthcare NHS Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,1,4]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24956"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1201\/b19781-9"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.14639\/0392-100X-1872"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.13820"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.28494"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348941312201108"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25708"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/1460-6984.12794"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-021-10287-3"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2013.03.002"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.696071"}],"container-title":["Clinical Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/coa.14138","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,13]],"date-time":"2024-04-13T01:29:56Z","timestamp":1712971796000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/coa.14138"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,4]]},"references-count":11,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1111\/coa.14138"],"URL":"https:\/\/doi.org\/10.1111\/coa.14138","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/COA.14138\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.14138\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.14138\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.14138\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.14138\/v1\/decision1","asserted-by":"object"}]},"ISSN":["1749-4478","1749-4486"],"issn-type":[{"value":"1749-4478","type":"print"},{"value":"1749-4486","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,4]]},"assertion":[{"value":"2023-01-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}