{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T15:24:28Z","timestamp":1788881068665,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T00:00:00Z","timestamp":1714694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Leukotrienes play a significant role in the pathogenesis of adenoid hypertrophy (A.H.). Therefore, we aimed to analyse the role of montelukast, a leukotriene receptor antagonist, alone or in combination with mometasone, a potent local intranasal steroid, for the treatment of A.H.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Participants were children with A.H. were treated with montelukast alone or montelukast and mometasone furoate. The main outcome measures were effect of montelukast on clinical symptoms of A.H. A literature review was conducted using online search engines, Cochrane Library, PubMed, Web of Science and Scopus, for randomized clinical trials assessing children with A.H. treated with montelukast alone or montelukast and mometasone furoate. Seven randomized clinical trials (RCTs) were included with 742 children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our study reveals that montelukast alone or in combination with intranasal mometasone furoate significantly improves clinical symptoms of adenoid hypertrophy such as snoring, sleeping disturbance, mouth breathing and A\/N ratio. Montelukast was superior to placebo in decreasing snoring (SMD\u2009=\u2009\u22121.00, 95% CI [\u22121.52, \u22120.49]), sleep discomfort (SMD\u2009=\u2009\u22121.26, 95% CI [\u22121.60, \u22120.93]), A\/N ratio (MD\u2009=\u2009\u22120.11, 95% CI [\u22120.14, \u22120.09]) and mouth breathing (SMD\u2009=\u2009\u22121.36, 95% CI [\u22121.70, \u22121.02]). No difference was detected between montelukast and mometasone versus mometasone alone in snoring (SMD\u2009=\u2009\u22120.21, 95%CI [\u22120.69, 0.27]); however, the combination group was superior to the mometasone alone in mouth breathing (SMD\u2009=\u2009\u22120.46, 95% CI [\u22120.73, \u22120.19]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The limitation of studies included a small sample size, with an overall low to medium quality. Thus, further larger, higher\u2010quality RCTs are recommended to provide more substantial evidence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/coa.14169","type":"journal-article","created":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T07:48:35Z","timestamp":1714722515000},"page":"417-428","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Efficacy of montelukast for adenoid hypertrophy in paediatrics: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6486-7066","authenticated-orcid":false,"given":"Farhan","family":"Alanazi","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Prince Sultan Military Medical City  Riyadh Kingdom of Saudi Arabia"},{"name":"Department of Otolaryngology Head and Neck Surgery Prince Mohammed Medical City  Al Jouf Kingdom of Saudi 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