{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:37:40Z","timestamp":1791902260876,"version":"4.3.4"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Tonsillectomy and adenoidectomy are common surgical procedures that cause persistent pain, bleeding, and functional limitations. We aimed to investigate the efficacy of celecoxib compared with a placebo for managing post\u2010tonsillectomy or adenoidectomy pain and other adverse events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Systematic review and meta\u2010analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a systematic literature search in the PubMed, Cochrane, and Google Scholar databases from inception until July 2023. Dichotomous outcomes have been reported as risk ratios (RR) while continuous outcomes were reported using mean differences (MD). A funnel plot was drawn to investigate publication bias.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      From 1394 records identified, 6 randomised double\u2010blind trials comprising 591 participants undergoing tonsillectomy and\/or adenoidectomy were eligible for inclusion. A high dose (400\u2009mg) of celecoxib was effective in decreasing the pain score for \u2018worst pain\u2019 after the procedure (MD: \u221210.98, [95% CI: \u221211.53, \u221210.42],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.01,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090%) while a low dose (200\u2009mg) was not significantly effective (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.31). For managing other outcomes such as vomiting (RR: 1.37 [95% CI: 0.69, 2.68],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.37,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200967%), diarrhoea (RR: 1.41, [95% CI: 0.75, 2.64],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.29,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200942%), dizziness\/drowsiness (RR: 0.90, [95% CI: 0.71, 1.15],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.48,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090%), functional recovery time (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.74), and headache (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.91), there was no significant difference between the group on celecoxib and the placebo group regardless of dosage. Finally, there was no significant difference (RR: 1.02, [95% CI: 0.91, 1.15],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.69,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090%) in the effect of the intervention on minimum bleeding, moderate bleeding, and profuse bleeding.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This meta\u2010analysis provides robust evidence pooled from high\u2010quality trials and raises questions about the efficacy of celecoxib for tonsillectomy and\/or adenoidectomy, challenging existing perceptions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/coa.14177","type":"journal-article","created":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T02:35:21Z","timestamp":1718418921000},"page":"578-587","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Assessing the efficacy of celecoxib after tonsillectomy and\/or adenoidectomy:\n                    <scp>A<\/scp>\n                    systematic review and meta\u2010analysis of randomised control trials"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2915-0634","authenticated-orcid":false,"given":"Umm E Salma Shabbar","family":"Banatwala","sequence":"first","affiliation":[{"name":"Department of Medicine Dow University of Health Sciences  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9670-9011","authenticated-orcid":false,"given":"Abdul Rehman Shah","family":"Syed","sequence":"additional","affiliation":[{"name":"Department of Medicine Dow University of Health Sciences  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noor Ul","family":"Ain","sequence":"additional","affiliation":[{"name":"Jinnah Sindh Medical University  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimen","family":"Zulfikar","sequence":"additional","affiliation":[{"name":"Department of Medicine Dow University of Health Sciences  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilqa Ikram","family":"Akhund","sequence":"additional","affiliation":[{"name":"Jinnah Sindh Medical University  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rija","family":"Lodhi","sequence":"additional","affiliation":[{"name":"Jinnah Sindh Medical University  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rameesha","family":"Baig","sequence":"additional","affiliation":[{"name":"Jinnah Sindh Medical University  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laiba","family":"Ghufran","sequence":"additional","affiliation":[{"name":"Jinnah Sindh Medical University  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayesha","family":"Rizwan","sequence":"additional","affiliation":[{"name":"Jinnah Sindh Medical University  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meena","family":"Bai","sequence":"additional","affiliation":[{"name":"Peoples University of Medical and Health Sciences for Women  Nawabshah Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahima","family":"Khatri","sequence":"additional","affiliation":[{"name":"Department of Medicine Dow University of Health Sciences  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satesh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Shaheed Mohtarma Benazir Bhutto Medical College Lyari  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,14]]},"reference":[{"key":"e_1_2_13_2_1","unstructured":"Nationwide Children's.Tonsillectomy and adenoidectomy [Internet]. 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Available from:https:\/\/www.webmd.com\/drugs\/2\/drug-16851-2379\/celecoxib-oral\/celecoxib-solution-oral\/details"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0000000000000346"},{"key":"e_1_2_13_16_1","volume-title":"StatPearls [Internet]","author":"Cohen B","year":"2023"},{"key":"e_1_2_13_17_1","unstructured":"PRISMA [Internet].PRISMA[cited 2023 Jun 17]. Available from:http:\/\/www.prisma-statement.org\/"},{"key":"e_1_2_13_18_1","unstructured":"Home | Cochrane Methods.RoB 2: a revised Cochrane risk\u2010of\u2010bias tool for randomized trials | Cochrane Bias [Internet][cited 2023 Jun 17]. 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