{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T05:10:46Z","timestamp":1782105046448,"version":"3.54.5"},"reference-count":52,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T00:00:00Z","timestamp":1717027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>To comprehensively evaluate the reported clinical effectiveness of platelet\u2010rich plasma (PRP) in patients with chronic sinusitis undergoing endoscopic sinus surgery (ESS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a systematic review and meta\u2010analysis of randomised controlled trials (RCTs). Five digital online databases (PubMed, Scopus, Web of Science, Google Scholar and Cochrane CENTRAL) were searched from inception up to 1st May 2023. Our specific outcomes involved postoperative nasal endoscopy scores measured via Lund\u2010Kennedy score or Meltzer score, olfactory sensation scores and pre\u2010operative anosmia duration. All data were pooled as standardised mean difference (SMD) with a 95% confidence interval (CI), using the RevMan software.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Six RCTs were included in this systematic review and meta\u2010analysis, with a total of 169 patients. The risk of bias in the included RCTs was low in three RCTs, some concerns in one RCT and high risk in two RCTs. The overall analysis of the postoperative nasal endoscopy scores showed that the PRP group had lower scores compared to the control group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20093 RCTs, SMD\u2009=\u2009\u22121.19; 95% CI [\u22121.94, \u22120.44],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.002). There was no significant difference between the PRP and control groups regarding anosmia duration (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092 RCTs, SMD\u2009=\u20090.21; 95% CI [\u22120.17, 0.59],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.28) or olfactory sensation scores, despite the PRP group having higher scores (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092 RCTs, SMD\u2009=\u20090.53; 95% CI [\u22120.32, 1.39],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.22).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study highlights the potential advantages of using PRP as an additional treatment for individuals with chronic sinusitis undergoing ESS. The improvements associated with PRP include facilitating wound healing, reducing inflammation and enhancing surgical outcomes. To optimise the use of PRP in clinical settings, future research should focus on conducting larger trials with standardised protocols.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/coa.14186","type":"journal-article","created":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T00:09:03Z","timestamp":1717114143000},"page":"567-577","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Platelet\u2010rich plasma following endoscopic sinus surgery in patients with chronic sinusitis: A systematic review and meta\u2010analysis of randomised controlled trials"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1244-7769","authenticated-orcid":false,"given":"Ebraheem","family":"Albazee","sequence":"first","affiliation":[{"name":"Kuwait Institute for Medical Specializations (KIMS)  Kuwait City 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