{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T10:43:28Z","timestamp":1773053008079,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T00:00:00Z","timestamp":1722297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objectives<\/jats:title>\n The aim is to investigate the influence of an active otitis media on the success rate of tympanoplasty in patients with a chronic otitis media (COM) and a tympanic membrane perforation.<\/jats:p>\n <\/jats:sec>\n \n Databases Reviewed<\/jats:title>\n PubMed, Embase and the Cochrane Library.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n The inclusion criteria were studies on closure rates of tympanoplasty performed in COM patients of any age with a tympanic membrane perforation caused by COM. The exclusion criteria were studies on patients undergoing concomitant mastoidectomy, ossicular chain reconstruction, tuboplasty, adenoidectomy, revision tympanoplasty, patients with perforations due to other conditions than COM, and letters to editors, commentaries, conference abstracts and case reports. The included articles were critically appraised using the QUIPS tool. Data on tympanic membrane closure rate were extracted, odds ratio (OR) and 95% confidence intervals (CI) of the closure rate with a wet versus a dry ear were calculated.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The search was performed on 1 February 2023. Of 4671 articles, 16 studies were included and critically appraised. Of these observational studies (nine prospective, seven retrospective), with a total of 1509 patients (dry ear group\n n<\/jats:italic>\n \u2009=\u20091003; wet ear group\n n<\/jats:italic>\n \u2009=\u2009506), two studies stated a significant difference in success rate, one in favour of a dry ear and one in favour of a wet ear at time of surgery. All other studies did not show a statistically significant difference. Overall, the risk of bias was considered moderate to high.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n We found no significant prognostic value of having an active otitis media during tympanoplasty on tympanic membrane closure rates. Because the overall risk of bias was considered moderate to high, no strong conclusions can be made. To be able to answer this question with higher levels of evidence, high\u2010quality prospective or randomized studies are needed.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/coa.14205","type":"journal-article","created":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T04:53:29Z","timestamp":1722315209000},"page":"699-712","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Prognostic Value of Active Otitis Media on Tympanoplasty Success Rate\u2014A Systematic Review"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-1107-2513","authenticated-orcid":false,"given":"Hanae Fumiyo","family":"Namba","sequence":"first","affiliation":[{"name":"Faculty of Medicine University of Utrecht Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5169-5065","authenticated-orcid":false,"given":"Mari\u00eblle Bernadette","family":"Plug","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Utrecht Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9126-9969","authenticated-orcid":false,"given":"Adriana Leni","family":"Smit","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery University Medical Center Utrecht Utrecht The Netherlands"},{"name":"Department of Neurology, UMC Utrecht Brain Center University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,30]]},"reference":[{"key":"e_1_2_11_2_1","article-title":"Topical Versus Systemic Antibiotics for Chronic Suppurative Otitis Media","volume":"2021","author":"Chong L. 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L.Durand \u201cChronic Otitis Media and Cholesteatoma in Adults \u201dUpToDate 2023 https:\/\/www.uptodate.com\/contents\/chronic\u2010otitis\u2010media\u2010and\u2010cholesteatoma\u2010in\u2010adults."},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-10-2089-6"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-74835-1"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-021-01626-4"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-144-6-200603210-00010"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.4103\/indianjotol.INDIANJOTOL_66_19"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940611501202"},{"key":"e_1_2_11_15_1","first-page":"709","article-title":"Myringoplasty in Children: Factors Influencing Surgical Outcome","volume":"118","author":"Caylan R.","year":"1998","journal-title":"Otolaryngology and Head and Neck Surgery"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12070-017-1075-8"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12070-020-01985-9"},{"key":"e_1_2_11_18_1","first-page":"341","article-title":"Determinants of Failure in the Reconstruction of the Tympanic Membrane: A Case\u2010Control Study","volume":"30","author":"Dispenza F.","year":"2018","journal-title":"Iranian Journal of Otorhinolaryngology"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215120001486"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00007516"},{"key":"e_1_2_11_21_1","first-page":"209","article-title":"Comparison of Tympanoplasty Results in Dry and Wet Ears","volume":"28","author":"Naderpour M.","year":"2016","journal-title":"Iranian Journal of Otorhinolaryngology"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1258\/0022215011907893"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otorri.2020.04.009"},{"key":"e_1_2_11_24_1","first-page":"MC01","article-title":"Study of Myringoplasty in Wet and Dry Ears in Mucosal Type of Chronic Otitis Media","volume":"10","author":"Santosh U. 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