{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T19:07:46Z","timestamp":1776280066464,"version":"3.50.1"},"reference-count":10,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T00:00:00Z","timestamp":1723420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005866","name":"Far Eastern Memorial Hospital","doi-asserted-by":"publisher","award":["FEMH\u20102023\u2010C\u2010025"],"award-info":[{"award-number":["FEMH\u20102023\u2010C\u2010025"]}],"id":[{"id":"10.13039\/501100005866","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Vocal process granuloma (VPG) is a chronic condition resulting from a mucoperichondrial injury of vocal process. Initial conservative treatment typically involves vocal hygiene education and antireflux medication. Treatment challenges arise with refractory cases. Outcomes of second\u2010line treatments such as surgical excision and botulinum toxin injections remain inconsistent. Thus, we propose this study to investigate the effectiveness of intralesional steroid injections for refractory VPG.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective review of 23 patients with VPG who showed no improvement after 3 months of proton pump inhibitors. These patients underwent one to three courses of monthly in\u2010office intralesional steroid injections as a second\u2010line therapy. Treatment outcomes were evaluated by measuring the size of the VPG relative to the length of the vocal folds before and after the final injection procedure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Results showed a significant reduction in VPG size from baseline of 27.74 \u00b1 15.06 to 5.48 \u00b1 8.95 (p &lt; .001). 15 out of 23 patients were responsive (size reduction \u2265 75%) to intralesional steroid injection. Alcohol consumption and longer symptom duration were associated with a poor response (size reduction &lt;75%), whereas prior intubation was associated with better response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>For refractory VPG not responding to conservative treatment, intralesional steroid injection appears to be a promising alternative option without significant adverse effects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/coa.14210","type":"journal-article","created":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T02:18:48Z","timestamp":1723515528000},"page":"822-826","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Treatment Outcomes of Intralesional Steroid Injection for Refractory Vocal Process Granuloma"],"prefix":"10.1111","volume":"49","author":[{"given":"Po\u2010Jun","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Far Eastern Memorial Hospital  New Taipei City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei\u2010Chen","family":"Hung","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Far Eastern Memorial Hospital  New Taipei City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9999-1291","authenticated-orcid":false,"given":"Chi\u2010Te","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Far Eastern Memorial Hospital  New Taipei City Taiwan"},{"name":"Department of Electrical Engineering Yuan Ze University  Taoyuan Taiwan"},{"name":"Department of Special Education University of Taipei  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,8,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003489414525921"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348941011900509"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-16-3303-4_17"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12021"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/sja.SJA_543_18"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215107000710"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2015.07.015"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2017.01.039"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21091"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agy063"}],"container-title":["Clinical Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/coa.14210","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T23:40:00Z","timestamp":1727998800000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/coa.14210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,12]]},"references-count":10,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1111\/coa.14210"],"URL":"https:\/\/doi.org\/10.1111\/coa.14210","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/COA.14210\/v3\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.14210\/v5\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.14210\/v5\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.14210\/v4\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.14210\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.14210\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.14210\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.14210\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.14210\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.14210\/v4\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.14210\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.14210\/v4\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.14210\/v5\/response1","asserted-by":"object"}]},"ISSN":["1749-4478","1749-4486"],"issn-type":[{"value":"1749-4478","type":"print"},{"value":"1749-4486","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,12]]},"assertion":[{"value":"2023-04-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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