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However, lignocaine is less potent than other local anaesthetics, and both active constituents of <jats:italic>Co\u2010phenylcaine<\/jats:italic> have a bitter taste. It was hypothesised that a combination spray containing tetracaine and oxymetazoline would both offer more potent topical anaesthesia and have a better taste.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Four anaesthetic\u2010decongestant nasal sprays were tested in 10 healthy participants (<jats:italic>Co\u2010phenylcaine<\/jats:italic>, and tetracaine 0.5%, 1% and 2% with oxymetazoline 0.05%). Sensory thresholds were sequentially measured at the head of the inferior turbinate using Semmes\u2010Weinstein monofilaments over the following hour. Participants also rated taste on a Likert\u2010style scale, and reported whether they experienced subjective numbness of the maxillary teeth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A median peak sensory threshold of 60\u2009g (the maximum tested) was observed with <jats:italic>Co\u2010phenylcaine<\/jats:italic>, but this threshold was exceeded by all the tetracaine\u2010based sprays. Tetracaine 2% with oxymetazoline 0.05% had a significantly more rapid onset than <jats:italic>Co\u2010phenylcaine<\/jats:italic> (4\u2009min vs. 6\u2009min, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) and a longer duration of action. Eight participants reported dental numbness after administration of tetracaine 2% with oxymetazoline 0.05%, but only one participant after <jats:italic>Co\u2010phenylcaine.<\/jats:italic> Tetracaine\u2010based sprays were generally perceived to taste less unpleasant than <jats:italic>Co\u2010phenylcaine.<\/jats:italic>\n<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Tetracaine 2% with oxymetazoline 0.05% is a more potent and rapidly acting anaesthetic\u2010decongestant spray than <jats:italic>Co\u2010phenylcaine<\/jats:italic>, with a longer duration of action.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.14223","type":"journal-article","created":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T18:08:24Z","timestamp":1726596504000},"page":"46-52","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Anaesthetic Efficacy of Tetracaine and Oxymetazoline Compared With <i>Co\u2010Phenylcaine<\/i> in Healthy Individuals"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5860-2448","authenticated-orcid":false,"given":"Samuel J. 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