{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:36:15Z","timestamp":1790699775108,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T00:00:00Z","timestamp":1733270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171154"],"award-info":[{"award-number":["82171154"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The first purpose of this study was to ascertain the distribution of unilateral M\u00e9ni\u00e8re's disease (MD) clinical subgroups in China and compare with the population reported in Europe and the United States. The second purpose was to investigate the effectiveness in different clinical phenotypes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Participants were categorised into one of five subtypes using a previously reported classification scheme based on cluster analysis. The distribution and clinical characteristics were analysed and compared with the two cohorts reported in Europe and the United States. Participants were followed up to observe the therapeutic effectiveness over a 2\u2010year period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 245 patients diagnosed with UMD were enrolled in the study, with 84 of these participants providing complete and detailed follow\u2010up data. All of the unilateral MD patients were accurately classified: 58.0% were classic MD, 25.7% were delayed MD, 1.2% was familial MD, 12.7% were sporadic MD with migraine and 2.4% were autoimmune MD. Our findings revealed a significant difference in the distribution between this cohort and the European cohort. Follow\u2010up assessments revealed worse vertigo control rate in the patients with migraine compared to the classical MD (50.0% vs. 82.6%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.034).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The distribution of unilateral MD subtypes in this Chinese population differs from that in the European population, and the therapeutic effectiveness varies across subtypes in this cohort. Our study highlights the importance of the clinical heterogeneity in unilateral MD, and further studies are needed to identify the optimal interventions for specific subgroups.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/coa.14264","type":"journal-article","created":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T05:03:17Z","timestamp":1733288597000},"page":"336-343","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Distribution and Therapeutic Effectiveness of Clinical Unilateral M\u00e9ni\u00e8re's Disease Phenotypes"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0949-9701","authenticated-orcid":false,"given":"Yongjia","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery, Xiangya Hospital Central South University  Changsha Hunan China"},{"name":"Otolaryngology Major Disease Research Key Laboratory of Hunan Province  Changsha Hunan China"},{"name":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinzhang","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery, Xiangya Hospital Central South University  Changsha Hunan China"},{"name":"Otolaryngology Major Disease Research Key Laboratory of Hunan Province  Changsha Hunan China"},{"name":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulu","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Public Health Xiangnan University  Chenzhou Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chufeng","family":"He","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery, Xiangya Hospital Central South University  Changsha Hunan China"},{"name":"Otolaryngology Major Disease Research Key Laboratory of Hunan Province  Changsha Hunan China"},{"name":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuewen","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery, Xiangya Hospital Central South University  Changsha Hunan China"},{"name":"Otolaryngology Major Disease Research Key Laboratory of Hunan Province  Changsha Hunan China"},{"name":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery, Xiangya Hospital Central South University  Changsha Hunan China"},{"name":"Otolaryngology Major Disease Research Key Laboratory of Hunan Province  Changsha Hunan China"},{"name":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongsheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery, Xiangya Hospital Central South University  Changsha Hunan China"},{"name":"Otolaryngology Major Disease Research Key Laboratory of Hunan Province  Changsha Hunan China"},{"name":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery, Xiangya Hospital Central South University  Changsha Hunan China"},{"name":"Otolaryngology Major Disease Research Key Laboratory of Hunan Province  Changsha Hunan China"},{"name":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Pang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery, Xiangya Hospital Central South University  Changsha Hunan China"},{"name":"Otolaryngology Major Disease Research Key Laboratory of Hunan Province  Changsha Hunan China"},{"name":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery, Xiangya Hospital Central South University  Changsha Hunan China"},{"name":"Otolaryngology Major Disease Research Key Laboratory of Hunan Province  Changsha Hunan China"},{"name":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anhai","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery, Xiangya Hospital Central South University  Changsha Hunan China"},{"name":"Otolaryngology Major Disease Research Key Laboratory of Hunan Province  Changsha Hunan China"},{"name":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5642-9661","authenticated-orcid":false,"given":"Mengzhu","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery, Xiangya Hospital Central South University  Changsha Hunan China"},{"name":"Otolaryngology Major Disease Research Key Laboratory of Hunan Province  Changsha Hunan China"},{"name":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huping","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery, Xiangya Hospital Central South University  Changsha Hunan China"},{"name":"Otolaryngology Major Disease Research Key Laboratory of Hunan Province  Changsha Hunan China"},{"name":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijiang","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery, Xiangya Hospital Central South University  Changsha Hunan China"},{"name":"Otolaryngology Major Disease Research Key Laboratory of Hunan Province  Changsha Hunan China"},{"name":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zequn","family":"Nie","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery, Xiangya Hospital Central South University  Changsha Hunan China"},{"name":"Otolaryngology Major Disease Research Key Laboratory of Hunan Province  Changsha Hunan China"},{"name":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3034-3322","authenticated-orcid":false,"given":"Lingyun","family":"Mei","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery, Xiangya Hospital Central South University  Changsha Hunan China"},{"name":"Otolaryngology Major Disease Research Key Laboratory of Hunan Province  Changsha Hunan China"},{"name":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,4]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000001227"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/01945998221106628"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ohn.610"},{"issue":"2","key":"e_1_2_12_5_1","first-page":"Cd015171","article-title":"Systemic Pharmacological Interventions for M\u00e9ni\u00e8re's Disease","volume":"2","author":"Webster K. E.","year":"2023","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2021.4282"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737175.2022.2030221"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599818773077"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21844"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-018-1927-7"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.21053\/ceo.2021.00920"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12844"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1017\/S002221511900255X"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.3233\/VES-150549"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(95)70102-8"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.01424"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10162-023-00896-0"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2016.00182"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-024-02643-8"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2012-001555"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ohn.386"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-23911-4"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2023.109632"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-022-01222-6"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016480701242469"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joto.2019.01.004"}],"container-title":["Clinical Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/coa.14264","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T08:02:29Z","timestamp":1738656149000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/coa.14264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,4]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1111\/coa.14264"],"URL":"https:\/\/doi.org\/10.1111\/coa.14264","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/COA.14264\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.14264\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.14264\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.14264\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.14264\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.14264\/v2\/response1","asserted-by":"object"}]},"ISSN":["1749-4478","1749-4486"],"issn-type":[{"value":"1749-4478","type":"print"},{"value":"1749-4486","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,4]]},"assertion":[{"value":"2024-08-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}