{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T11:51:26Z","timestamp":1791546686961,"version":"4.3.4"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,1,12]],"date-time":"2025-01-12T00:00:00Z","timestamp":1736640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009232","name":"Beatson Cancer Charity","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009232","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This descriptive epidemiological study aims to investigate trends in head and neck cancer (HNC) within the anatomical divisions of laryngeal, oropharyngeal, and oral cavity cancers over the past two decades.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Retrospective population\u2010based observational study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Scotland, a constituent country of the United Kingdom, with a population of 5.5 million.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Newly diagnosed HNC patients in Scotland registered in the Scottish Cancer Registry from 2001 to 2020.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures<\/jats:title>\n                    <jats:p>Trends in age\u2010standardised incidence rates from 2001 to 2020 for each HNC subsite, anatomical division, and individual sociodemographic using joinpoint regression analysis and Poisson regression analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, HNC incidence rates have remained stable, with an average annual percentage change (AAPC) of 0.29% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.34). However, oropharyngeal cancer showed a significant increase in incidence rates with an AAPC of 3.76% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001); the tonsils (C09) and the base of the tongue (C01) experienced the greatest increases in AAPC of 4.63% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) and 4.79% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), respectively. Conversely, laryngeal cancer rates declined significantly, with an AAPC of \u22122.56% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). This decline was primarily influenced by annual reductions of \u22122.40% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.09) in cancers affecting the glottis (C32.0). Incidence rates for oral cavity cancer remained mostly stable, with an AAPC of \u22120.60% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.08).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This analysis highlights that behind a stable HNC incidence rate over the past 20\u2009years, there are differential trends among various anatomical divisions with an overall increasing burden of oropharyngeal cancer and declining rates of laryngeal cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/coa.14271","type":"journal-article","created":{"date-parts":[[2025,1,12]],"date-time":"2025-01-12T19:40:11Z","timestamp":1736710811000},"page":"474-484","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Incidence Trends in Head and Neck Cancer 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