{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T01:19:27Z","timestamp":1787879967499,"version":"build-2784847793"},"reference-count":53,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T00:00:00Z","timestamp":1740873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["203919\/Z\/16\/Z"],"award-info":[{"award-number":["203919\/Z\/16\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Tympanic membrane perforation can cause hearing impairment with detrimental effects on communication and quality of life, and is a problem affecting an estimated 250 million people. To date, there is little analysis to inform public policy on options for assistive hearing technology rehabilitation in this group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We undertook a systematic review and meta\u2010analysis of six electronic databases registered with PROSPERO and reported in accordance with PRISMA 2020 standards. The primary outcome was the mean air and bone conduction hearing threshold associated with tympanic perforation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 720 studies identified, 16 contained data for meta\u2010analysis. Mean air conduction threshold was 48.3\u2009dB HL in adults and 31.9\u2009dB HL in children. Mean bone conduction was 26.6\u2009dB HL in adults and 9.5\u2009dB HL in children. The prediction interval was \u22121.7 to 46.7\u2009dB HL for bone conduction and 15.0\u201370.5\u2009dB HL for air conduction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The majority of adults and children with tympanic perforation have air conduction thresholds within the range of rehabilitation with air conduction hearing aids. The majority also have good sensorineural hearing reserve, meaning bone conduction devices are also suitable. Our analysis can guide the development of affordable technology for the rehabilitation of those with tympanic perforation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/coa.14295","type":"journal-article","created":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T22:34:15Z","timestamp":1741041255000},"page":"589-599","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Systematic Review and Meta\u2010Analysis of Audiometric Parameters for Assistive Hearing Technology for Adults and Children With Tympanic Membrane Perforation"],"prefix":"10.1111","volume":"50","author":[{"given":"Thomas","family":"Hampton","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences Liverpool School of Tropical Medicine  Liverpool UK"},{"name":"Institute of Life Course and Medical Sciences University of Liverpool  Liverpool 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