{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T22:39:26Z","timestamp":1784241566559,"version":"3.55.0"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T00:00:00Z","timestamp":1745539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The ETDQ\u20107 questionnaire has been validated for diagnosing Eustachian tube dysfunction (ETD) and a minimal clinically important difference (MCID) of &gt;\u20093.5 has been suggested. We aim to assess the use of ETDQ\u20107 for assessing ETD and a potential correlation between ETDQ\u20107 and the Sino\u2010Nasal Outcome Test 22 (SNOT\u201022).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>ETD was based on relevant ear symptoms and objective signs of negative middle ear pressure in 75 consecutive adult patients. Ventilation tube insertion (VTi) was performed on affected ears. ETDQ\u20107 and SNOT\u201022 scores before and 1 month after VTi were compared to 75 healthy controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mean ETDQ\u20107 score decreased from 31.9 to 15.8 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001), remained stable on unaffected ears, and was 9.6 in controls. MCID was achieved on all affected ears after VTi. A cut\u2010off score of &gt;\u200914.5 for diagnosing ETD yielded 100% sensitivity and 94.2% specificity for ETDQ\u20107. Spearman's\n                      <jats:italic>\u03c1<\/jats:italic>\n                      for total score test\u2013retest was 0.878 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.000). Cronbach alpha for total score varied from 0.6807 to 0.7266. SNOT\u201022 and ETDQ\u20107 were correlated at baseline (0.12,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.012). ETD patients scored significantly higher in the nasal, otologic and sleep domains in SNOT\u201022 compared to controls.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>ETDQ\u20107 is a very valid tool for ETD diagnostics and assessing the ear\u2010related effects of VTi. ETDQ\u20107 scores reveal residual symptoms after VTi, indicating symptom relief but no cure for the underlying pathophysiology. For future investigation, we suggest assessing ETDQ\u20107 scores for each ear separately, higher MCID values, and integration of quality of life measures.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      : NCT05055115\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/coa.14324","type":"journal-article","created":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T06:00:22Z","timestamp":1745560822000},"page":"840-847","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Usefulness of\n                    <scp>ETDQ<\/scp>\n                    \u20107 Score in Assessing\n                    <scp>ETD<\/scp>"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9674-764X","authenticated-orcid":false,"given":"Niels H\u00f8jvang","family":"Holm","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery G\u00f8dstrup Hospital  Herning Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0864-7987","authenticated-orcid":false,"given":"Therese","family":"Ovesen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,25]]},"reference":[{"key":"e_1_2_12_2_1","first-page":"1","volume-title":"Eustachian Tube: Structure, Function, Role in Otitis Media","author":"Bluestone C. D.","year":"2005"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12475"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23223"},{"issue":"3","key":"e_1_2_12_5_1","first-page":"160","article-title":"Assessment of Chronic Obstructive Eustachian Tube Dysfunction: Evaluation of the German Version of the Eustachian Tube Dysfunction Questionnaire","volume":"62","author":"Schr\u00f6der S.","year":"2014","journal-title":"Hals\u2010Nasen\u2010Ohrenheilkunde"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjorl.2017.05.001"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjorl.2018.03.010"},{"issue":"7","key":"e_1_2_12_8_1","article-title":"Validating the 7\u2010Item Eustachian Tube Dysfunction Questionnaire in Danish","volume":"67","author":"Hansen L. J.","year":"2020","journal-title":"Danish Medical Journal"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26827"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22942"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1037\/0021-9010.78.1.98"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-019-05320-z"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00106-020-00931-z"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016489.2017.1366053"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000001931"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2007.11.002"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(97)70127-1"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1081\/JAS-200044744"}],"container-title":["Clinical Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/coa.14324","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T08:02:08Z","timestamp":1754294528000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/coa.14324"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,25]]},"references-count":17,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1111\/coa.14324"],"URL":"https:\/\/doi.org\/10.1111\/coa.14324","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/COA.14324\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.14324\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.14324\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.14324\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.14324\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.14324\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.14324\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.14324\/v1\/decision1","asserted-by":"object"}]},"ISSN":["1749-4478","1749-4486"],"issn-type":[{"value":"1749-4478","type":"print"},{"value":"1749-4486","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,25]]},"assertion":[{"value":"2024-03-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}