{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T12:13:13Z","timestamp":1791807193134,"version":"4.3.4"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T00:00:00Z","timestamp":1746316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Functional endoscopic sinus surgery (FESS) has been shown to be effective in improving health\u2010related quality of life (HRQoL) in patients with chronic rhinosinusitis with nasal polyps (CRSwNP), though patient selection remains crucial for optimising outcomes. This study aimed to identify predictors of improved postoperative HRQoL and predictors of revision surgery in CRSwNP patients undergoing FESS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Tertiary referral hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>A total of 153 patients were enrolled in this study. They were asked to fill out the Endonasal Endoscopic Sinus and Skull Base Surgery Questionnaire (EES\u2010Q) preoperatively, and then at 2\u2009weeks, 3\u2009months and 1\u2009year postoperatively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures<\/jats:title>\n                    <jats:p>Linear mixed model (LMM) analyses were performed to evaluate the overall postoperative HRQoL and the separate health domains, as well as the impact of specific variables (sex, age, ASA classification, smoking, asthma, aspirin\u2010exacerbated respiratory disease, allergic rhinitis, Lund\u2013Mackay score, surgical procedure, postoperative antibiotics, postoperative prednisolone, FESS history, eosinophilia and preoperative EES\u2010Q score) on HRQoL improvement. Using the same variables, a logistic regression analysis was performed to identify predictors of revision surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The total EES\u2010Q score (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), as well as the physical (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and social (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) domains, significantly improved postoperatively. In the LMM analysis, the preoperative EES\u2010Q score was the only significant variable on the postoperative HRQoL outcome (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Eosinophilia was the only significant variable on revision surgery (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.036).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>FESS significantly improved postoperative HRQoL. Patients reporting worse preoperative HRQoL showed the greatest improvement postoperatively. Proven eosinophilia was the only significant predictor of revision surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/coa.14331","type":"journal-article","created":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T19:21:33Z","timestamp":1746386493000},"page":"856-863","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Exploring Predictors of Post\u2010Surgical Health\u2010Related Quality of Life and Revision Surgery in Patients With Chronic Rhinosinusitis With Nasal Polyps: A Cohort Study"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0425-613X","authenticated-orcid":false,"given":"Marc C.","family":"den Heijer","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery University Medical Center Groningen, University of Groningen  Groningen the Netherlands"},{"name":"Graduate School of Medical Sciences University of Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2632-6198","authenticated-orcid":false,"given":"Merel M.","family":"van der Ven","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery University Medical Center Groningen, University of Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8171-0546","authenticated-orcid":false,"given":"Gonneke E.","family":"Joustra","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery University Medical Center Groningen, University of Groningen  Groningen the Netherlands"},{"name":"Graduate School of Medical Sciences University of Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9257-2791","authenticated-orcid":false,"given":"Karin M.","family":"Vermeulen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University Medical Center Groningen, University of Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8568-0847","authenticated-orcid":false,"given":"Robert A.","family":"Feijen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery University Medical Center Groningen, University of Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5094-7698","authenticated-orcid":false,"given":"Astrid G. W.","family":"Korsten\u2010Meijer","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery University Medical Center Groningen, University of Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,4]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2016.12.012"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2016.30.4343"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-020-00904-w"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2016.30.4297"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2020.09.063"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22741"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12070-020-01855-4"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-013-2626-6"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(21)00457-4"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-020-00932-6"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22505"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22487"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin20.600"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22000"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2014.09.003"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599818773065"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2007.21.2978"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.27008"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21406"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.14158"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/lio2.1004"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.13962"},{"issue":"4","key":"e_1_2_11_24_1","first-page":"261","article-title":"Twelve\u2010Year Long\u2010Term Postoperative Outcomes in Patients With Chronic Rhinosinusitis With Nasal Polyps","volume":"60","author":"Arancibia C.","year":"2022","journal-title":"Rhinology"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22886"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amsu.2019.03.001"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-024-01154-w"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21979"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/1945892420936196"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0192330"}],"container-title":["Clinical Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/coa.14331","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T08:01:51Z","timestamp":1754294511000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/coa.14331"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,4]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1111\/coa.14331"],"URL":"https:\/\/doi.org\/10.1111\/coa.14331","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/COA.14331\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.14331\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.14331\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.14331\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.14331\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.14331\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.14331\/v1\/review2","asserted-by":"object"}]},"ISSN":["1749-4478","1749-4486"],"issn-type":[{"value":"1749-4478","type":"print"},{"value":"1749-4486","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,4]]},"assertion":[{"value":"2024-12-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}