{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T20:08:26Z","timestamp":1775160506526,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T00:00:00Z","timestamp":1748476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>This study aimed to determine the effects of cisplatin on vestibular function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Prospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We measured vestibulo\u2010ocular reflex gain (VOR gain), cervical vestibular\u2010evoked myogenic potential amplitude (cVEMP amplitude) and hearing acuity before and after treatment in 28 patients treated with cisplatin\u2010based chemoradiation to determine changes in hearing and vestibular function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      VOR gain did not decrease significantly before and after treatment, but cVEMP amplitude decreased significantly (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). Air and bone hearing level worsened significantly (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). The VOR gain in the group receiving more than 200\u2009mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      of cisplatin was significantly decreased compared with the group receiving less than 200\u2009mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). The cVEMP amplitude and hearing level were not significantly different between the two groups. Even after adjusting for age and inner ear radiation dose, VOR gain was inversely related to increasing cisplatin dose (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.19; SE\u2009=\u20090.08).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients treated with cisplatin\u2010based chemoradiotherapy exhibited decreased VOR gain. Patients should undergo vestibular and auditory testing before and after chemoradiation to detect potential vestibular impairment earlier, and prompt initiation of vestibular physical therapy would increase patients' quality of life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/coa.14335","type":"journal-article","created":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T20:34:52Z","timestamp":1748550892000},"page":"883-889","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Quantitative Assessment of Vestibular Function by Video Head Impulse Test and Vestibular\u2010Evoked Myogenic Potential During Cisplatin\u2010Based Chemoradiation"],"prefix":"10.1111","volume":"50","author":[{"given":"Natsuki","family":"Takada","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Gifu University Graduate School of Medicine  Gifu Japan"},{"name":"Department of Otolaryngology Gifu Prefectural General Medical Center  Gifu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8374-3798","authenticated-orcid":false,"given":"Hiroshi","family":"Okuda","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Gifu University Graduate School of Medicine  Gifu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirofumi","family":"Shibata","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Gifu University Graduate School of Medicine  Gifu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natsuko","family":"Obara","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Gifu University Graduate School of Medicine  Gifu 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