{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:18:48Z","timestamp":1791310728093,"version":"4.3.1"},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Sudden sensorineural hearing loss (SSNHL) is an otologic emergency and is treated with steroid therapy. Despite adverse events (AEs) associated with long\u2010term steroid use being well evidenced, there is sparsity of literature regarding the AEs of short\u2010course prescriptions in the SSNHL cohort, which limits the quality of patient counselling and informed consent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>A literature search was performed on the Medline and Embase databases for studies assessing AEs in adults with SSNHL managed with oral (OST), intratympanic (ITS) and intravenous steroid therapy (IVS). Two authors screened titles, abstracts and full\u2010text articles, with conflicts resolved by a third reviewer. Forty\u2010three papers were included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In systemic steroid therapies, hyperglycaemia and hypertension are reported in up to 29.8% and 37.9% of patients respectively. Patients with medication\u2010dependent diabetes and hypertension are at higher risk. Gastric and mood disturbances affected up to 27.9% and 44.6% of patients respectively. ITS carried risks of otalgia (up to 54.3%), dizziness (up to 27.1%), perforations (up to 11.5%) and otitis media (up to 4.7%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Comprehensive counselling is key in obtaining informed consent, especially in cohorts with diabetes mellitus (DM) and hypertension where monitoring of glucose and blood pressure is recommended. Gastroprotection should be considered. Future focus is required to study short\u2010term steroid AEs and raise awareness among prescribing clinicians and patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/coa.14339","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T05:53:57Z","timestamp":1748584437000},"page":"821-830","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Adverse Effects of Steroid Therapy in Sudden Sensorineural Hearing Loss: A Scoping Review"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5135-3971","authenticated-orcid":false,"given":"M.","family":"Achanta","sequence":"first","affiliation":[{"name":"Imperial College Healthcare NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Kasetti","sequence":"additional","affiliation":[{"name":"School of Medicine Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Fortune\u2010Ely","sequence":"additional","affiliation":[{"name":"Imperial College Healthcare NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4211-6418","authenticated-orcid":false,"given":"T.","family":"Ross","sequence":"additional","affiliation":[{"name":"University College London Hospitals NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4167-205X","authenticated-orcid":false,"given":"T.","family":"Magos","sequence":"additional","affiliation":[{"name":"University College London Hospitals NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. G.","family":"Manjaly","sequence":"additional","affiliation":[{"name":"University College London Hospitals NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,30]]},"reference":[{"key":"e_1_2_12_2_1","volume-title":"Management of Suspected Unilateral Idiopathic Sudden Sensorineural Hearing Loss in Adults","author":"Twigg V.","year":"2020"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-022-07264-3"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.7874\/kja.2012.16.2.65"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e318168da7a"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008080.pub2\/full"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.679"},{"key":"e_1_2_12_8_1","unstructured":"R.Mandavia \u201cPrognostic Factors for Outcomes of Idiopathic Sudden Onset Sensorineural Hearing Loss: The SeaSHeL National Prospective Cohort Study.\u201d(2023) http:\/\/www.seashel.co.uk\/about\u2010us\/."},{"key":"e_1_2_12_9_1","unstructured":"\u201cSTARFISH\u2014INTEGRATE \u201dCited 2024 Oct 20 https:\/\/entintegrate.co.uk\/starfish."},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21984"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2023.1142459"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0111479"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/EVIDoa2300172"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2009.06.084"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.4103\/njcp.njcp_661_22"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599813500754"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjorl.2018.06.001"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2004.09.072"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-011-1523-0"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-017-4691-8"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e3181585428"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2009.08.009"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1159\/000508124"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215110002124"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300060518802725"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940711600405"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016489.2019.1592221"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2024.104258"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016489.2018.1535192"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599815615121"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e318206fdfa"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.35755\/jmedassocthai.2022.06.13328"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.13706"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.28231"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2005.01.024"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000000834"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e31828bb567"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599811418169"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2010.07.008"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v8.i18.4051"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2010.06.007"},{"key":"e_1_2_12_42_1","volume-title":"Endotext","author":"Nicolaides N. 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