{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:59:57Z","timestamp":1787317197677,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T00:00:00Z","timestamp":1750636800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>CRS is a multifactorial pathology associated with inflammatory comorbidities including asthma, allergic rhinitis (AR) and nasal polyposis (NP). The systemic immune\u2010inflammatory index (SII) has been shown to have prognostic efficacy in gauging systemic inflammation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the potential utility of the SII in assessing the extent of surgery and CRS\u2010mediated comorbidities in patients undergoing ESS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      13\u2010year retrospective study of 147 adults undergoing ESS with preoperative platelet, neutrophil and lymphocyte counts for SII calculation ((platelets\u2009\u00d7\u2009neutrophils)\/lymphocytes). Lund\u2010Mackay scores, surgery extent and comorbidities were collected. For analyses, numeric versus categorical utilised a two\u2010tailed\n                      <jats:italic>t<\/jats:italic>\n                      \u2010test, categorical versus categorical utilised a Chi\u2010square test of independence. Significance set at\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      147 patients met criteria, 75 had CRS and 72 had other sinonasal conditions (exploratory control). Average SII for all patients was 1080.6\u2009\u00b1\u20091134.6 (range 0\u20138119, median 735). Significant differences in average SII existed between CRS and other sinonasal disorders (1479\u2009\u00b1\u20091186 vs. 1007\u2009\u00b1\u20091082,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.013). No significant differences were found in Lund\u2010McKay scores between CRS patients with SII above or below previously reported critical thresholds (i.e., SII\u2009&gt;\u2009330 or &gt;\u2009895.6). Significant inverse association was observed between comorbidities and SII in CRS patients; those with SII\u2009&lt;\u2009895.6 had statistically significant higher prevalence of asthma (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) and AR (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0143). No association was found between SII and nasal polyps, or with number of sinuses opened during surgery.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CRS patients requiring ESS had higher SII values than those with other indications. Contrary to previous reports, our study found that SII in CRS patients was inversely associated with asthma and AR, and was not associated with surgical extent.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/coa.70001","type":"journal-article","created":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T06:39:19Z","timestamp":1750660759000},"page":"967-972","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Investigating Utility of the Preoperative Systemic Immune\u2010Inflammatory Index in Chronic Rhinosinusitis"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-9062-7619","authenticated-orcid":false,"given":"Abdullah A.","family":"Memon","sequence":"first","affiliation":[{"name":"Department of Otolaryngology and Communication Sciences Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Poetker","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Communication Sciences Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jazzmyne","family":"Adams","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Communication Sciences Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Friedland","sequence":"additional","affiliation":[{"name":"Caruso Department of Otolaryngology \u2013 Head &amp; Neck Surgery Keck School of Medicine of the University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren M.","family":"North","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Communication Sciences Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,23]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12577"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2004.09.067"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2023.05.015"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/03007995.2020.1815682"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2020.09.063"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2016.04.012"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21258"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.111593"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2002.122458"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201014\u20100442"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2023.1199433"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.933913"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0b013e32836344d3"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405\u2010023\u201008182\u20108"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599815572097"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194\u201059989770005\u20106"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/crj.13314"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1205687"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11908\u2010011\u20100166\u2010z"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2016.09.439"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22289"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3786"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22214"}],"container-title":["Clinical Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/coa.70001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T04:01:06Z","timestamp":1759377666000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/coa.70001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,23]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1111\/coa.70001"],"URL":"https:\/\/doi.org\/10.1111\/coa.70001","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/COA.70001\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.70001\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.70001\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.70001\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.70001\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.70001\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.70001\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.70001\/v3\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.70001\/v3\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.70001\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.70001\/v2\/decision1","asserted-by":"object"}]},"ISSN":["1749-4478","1749-4486"],"issn-type":[{"value":"1749-4478","type":"print"},{"value":"1749-4486","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,23]]},"assertion":[{"value":"2025-03-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}