{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:41:33Z","timestamp":1772160093990,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T00:00:00Z","timestamp":1754179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>There is a lack of comprehensive data on complications following sinus surgery (SS) in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). This study aimed to estimate the prevalence of SS\u2010related complications in CRSwNP patients and examine patient characteristics, predictors of revision surgery, healthcare use, and associated costs using secondary care data from Swedish registers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This observational cohort study used Swedish administrative register data to report patient characteristics and estimate the prevalence and incidence of SS\u2010related complications among CRSwNP patients. Healthcare resource use (HCRU) and associated costs, the probability of and predictors for revision surgery were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Out of 9178 CRSwNP patients who underwent SS, 8.5% experienced complications to SS. Asthma was the most frequently observed comorbidity. The probability of revision surgery within 4\u2009years was 12%. Factors such as younger age at index, complications to first surgery, earlier index year, and comorbid asthma were significant predictors for future surgery. Within 4\u2009years of follow\u2010up, patients undergoing SS showed more HCRU and higher related costs compared to matched general population controls (\u20ac13\u2009865 vs. \u20ac7088 per person;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Asthma comorbidity, the occurrence of complications, and undergone revision surgery were associated with higher costs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Overall, this study provides valuable clinical insights into patient characteristics, complications to SS, resource use, and factors related to revision surgery in patients with CRSwNP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/coa.70009","type":"journal-article","created":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T05:03:41Z","timestamp":1754283821000},"page":"1061-1070","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Complications and Economic Burden of Surgery in Chronic Rhinosinusitis With Nasal Polyps: An Observational Cohort Study Using Swedish Register Data"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3913-3914","authenticated-orcid":false,"given":"Petter","family":"Olsson","sequence":"first","affiliation":[{"name":"Division of Ear, Nose, and Throat Diseases, Department of Clinical Sciences, Intervention and Technology Karolinska Institutet  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1680-8480","authenticated-orcid":false,"given":"Christoph","family":"Ab\u00e9","sequence":"additional","affiliation":[{"name":"Quantify Research  Stockholm Sweden"},{"name":"Department of Clinical Neuroscience Karolinska Institutet  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9046-8930","authenticated-orcid":false,"given":"Maija","family":"Wolf","sequence":"additional","affiliation":[{"name":"Novartis Finland  Espoo Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7927-3770","authenticated-orcid":false,"given":"Mathias","family":"Lilja","sequence":"additional","affiliation":[{"name":"Quantify Research  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tina","family":"Maio\u2010Twofoot","sequence":"additional","affiliation":[{"name":"Novartis Pharma AG  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1192-0182","authenticated-orcid":false,"given":"Ola","family":"Sunnergren","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology  J\u00f6nk\u00f6ping Sweden"},{"name":"Centre for Oral Health, School of Health and Welfare J\u00f6nk\u00f6ping University  J\u00f6nk\u00f6ping Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5146-3636","authenticated-orcid":false,"given":"Pernilla","family":"Sahlstrand\u2010Johnson","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery Sk\u00e5ne University Hospital, Lund University  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,3]]},"reference":[{"issue":"29","key":"e_1_2_14_2_1","first-page":"1","article-title":"European Position Paper on Rhinosinusitis and Nasal Polyps 2020","volume":"58","author":"Fokkens W. 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