{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T16:51:34Z","timestamp":1788454294258,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,8,17]],"date-time":"2025-08-17T00:00:00Z","timestamp":1755388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>This study aimed to investigate the potential prognostic value of eosinophil count, eosinophil\u2010monocyte ratio (EMR), total IgE, systemic immune\u2010inflammatory index (SII), systemic inflammation response index (SIRI), neutrophil\u2010lymphocyte ratio (NLR), platelet\u2010lymphocyte ratio (PLR), and the presence of asthma and acetylsalicylic acid (ASA) sensitivity in predicting postoperative recurrence in patients with chronic rhinosinusitis with nasal polyposis (CRSwNP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with CRSwNP were divided into two groups based on recurrence within 3\u2009years postoperatively: Group 1 (non\u2010recurrent) included patients with no signs of recurrence, and Group 2 (recurrent) included those with endoscopic evidence of recurrence. A control group of age\u2010 and gender\u2010matched healthy individuals without any history of inflammation and with normal nasal endoscopy findings was also included. Eosinophil, EMR, total IgE, NLR, PLR, SII, SIRI, and the presence of asthma and ASA sensitivity were compared among the groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The recurrent NP group had significantly higher median total IgE and PLR compared to the non\u2010recurrent group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.036). Compared to controls, the recurrent NP group had significantly elevated eosinophil, EMR, SII, and SIRI levels (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.022, and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.038, respectively). No significant differences in PLR, SII, or SIRI were found between the non\u2010recurrent and control groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20091). Multivariate logistic regression identified asthma as an independent predictor of recurrence.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>EMR, SII, and SIRI may serve as valuable biomarkers in CRSwNP. Their elevated levels in recurrent cases support their potential role in predicting postoperative recurrence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/coa.70024","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T06:22:11Z","timestamp":1755498131000},"page":"1096-1102","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Beyond the\n                    <scp>CBC<\/scp>\n                    : Can Novel Markers Predict Recurrence in Chronic Rhinosinusitis With Nasal Polyposis?"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7047-0081","authenticated-orcid":false,"given":"Hasan","family":"Canakci","sequence":"first","affiliation":[{"name":"Department of Otolaryngology University Medical Center Balikesir  Balikesir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3469-2653","authenticated-orcid":false,"given":"Hasmet","family":"Yazici","sequence":"additional","affiliation":[{"name":"Private Clinic  Balikesir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9333-4347","authenticated-orcid":false,"given":"Salih","family":"Yayman","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University Medical Center Balikesir  Balikesir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6783-2133","authenticated-orcid":false,"given":"Kamil Gokce","family":"Tulaci","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University Medical Center Balikesir  Balikesir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6799-8907","authenticated-orcid":false,"given":"Erhan","family":"Arslan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Etlik City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6822-2679","authenticated-orcid":false,"given":"Omer","family":"Hizli","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University Medical Center Balikesir  Balikesir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1258\/002221503321046577"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.2500\/108854196778662264"},{"key":"e_1_2_11_4_1","first-page":"261","article-title":"Twelve\u2010Year Long\u2010Term Postoperative Outcomes in Patients With Chronic Rhinosinusitis With Nasal Polyps","volume":"60","author":"Arancibia C.","year":"2022","journal-title":"Rhinology"},{"key":"e_1_2_11_5_1","first-page":"133","article-title":"The Correlation Between Preoperative Neutrophil\u2010To\u2010Lymphocyte Ratio and Platelet\u2010To\u2010Lymphocyte Ratio and Postoperative Recurrence of Chronic Rhinosinusitis","volume":"38","author":"Zhang Y.","year":"2024","journal-title":"Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCA.0000000000001037"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30057"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22994"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-022-01312-0"},{"key":"e_1_2_11_10_1","first-page":"502","article-title":"Risk Factors and Comorbidities of Recurrent Nasal Polyposis","volume":"23","author":"Esmaeilzadeh H.","year":"2024","journal-title":"Iranian Journal of Allergy, Asthma, and Immunology"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S309923"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2007.02.004"},{"key":"e_1_2_11_13_1","first-page":"169","article-title":"Endoscopic Grading Systems for Nasal Polyps: Are We Comparing Apples to Oranges?","volume":"60","author":"Djupesland P. 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Assessment of Its Diagnostic Accuracy","volume":"120","author":"Esquivel\u2010Esquivel N.","year":"2022","journal-title":"Archivos Argentinos de Pediatr\u00eda"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-023-08182-8"},{"key":"e_1_2_11_23_1","first-page":"102","article-title":"Factors Associated With Recurrent Nasal Polyps: A Tertiary Care Experience","volume":"60","author":"Akhtar S.","year":"2010","journal-title":"Journal of the Pakistan Medical Association"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-018-5032-2"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/27534030241274764"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.31846"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-015-3753-z"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-39150-0"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S339221"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S283835"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2020.09.063"}],"container-title":["Clinical Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/coa.70024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T04:00:50Z","timestamp":1759377650000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/coa.70024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,17]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1111\/coa.70024"],"URL":"https:\/\/doi.org\/10.1111\/coa.70024","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/COA.70024\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.70024\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.70024\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.70024\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.70024\/v1\/review1","asserted-by":"object"}]},"ISSN":["1749-4478","1749-4486"],"issn-type":[{"value":"1749-4478","type":"print"},{"value":"1749-4486","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,17]]},"assertion":[{"value":"2025-04-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}