{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T03:11:12Z","timestamp":1792206672832,"version":"4.4.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T00:00:00Z","timestamp":1758412800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371129"],"award-info":[{"award-number":["82371129"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Obstructive sleep apnea (OSA) is currently viewed as a chronic, multisystem condition associated with an increased risk of cognitive impairment, especially mild cognitive impairment (MCI). As biomarkers of neurodegeneration, we evaluated whether neurofilament light (NfL), amyloid\u2010\u03b2 42(A\u03b2\u201042) and amyloid\u2010\u03b2 40 (A\u03b2\u201040) can be used to indicate MCI in OSA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>A cross\u2010sectional study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Single\u2010centre trial at tertiary medical institutions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>A total of 153 newly diagnosed subjects with OSA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcomes Measures<\/jats:title>\n                    <jats:p>All participants completed polysomnography, neuropsychological assessments, and plasma biomarkers of neurodegeneration detection, including NfL, A\u03b2\u201042 and A\u03b2\u201040.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared to the cognitively normal group, only the levels of plasma NfL were increased in the MCI group. The plasma NfL levels were associated with an increased risk of cognitive impairment in OSA patients after adjusting for age, gender, body mass index, and education year. Plasma NfL outperformed other biomarkers in differentiating MCI from normal cognition (area under the ROC curve [AUC]\u2009=\u20090.829). Plasma NfL, in combination with conventional factors (age, body mass index, smoking, alcohol consumption, diabetes mellitus, hypertension, history of snoring, history of apneic episodes and time ratio of SaO\n                      <jats:sub>2<\/jats:sub>\n                      \u2009&lt;\u200990%) yielded an AUC of 0.907 for differentiating between MCI and normal cognition.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings indicate that the plasma NfL was increased in OSA patients with cognitive impairment. Furthermore, plasma NfL appears to be superior to plasma A\u03b2 for identifying MCI in OSA and holds potential as an objective biomarker associated with MCI in these patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/coa.70035","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T03:14:27Z","timestamp":1758510867000},"page":"92-100","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Exploration of Plasma Biomarkers of Neurodegeneration in Obstructive Sleep Apnea\u2014Related Mild Cognitive Impairment"],"prefix":"10.1111","volume":"51","author":[{"given":"Lina","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery The Second Affiliated Hospital of Xi'an Jiaotong University  Xi'an 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Hospital of Xi'an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonglong","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery The Second Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yushan","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery The Second Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yewen","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery The Second Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"},{"name":"Shaanxi Provincial Key Laboratory for Precision Diagnosis and Treatment of Otorhinolaryngology  Xi'an 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