{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:41:34Z","timestamp":1772160094134,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T00:00:00Z","timestamp":1759363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The aim of this study was to develop and validate a clinical prediction model to predict the occurrence of persistent hypoparathyroidism after total or completion thyroidectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicentre retrospective cohort study included patients who underwent total or completion thyroidectomy between January 2010 and June 2021 in 12 Dutch hospitals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 366 patients included, 44 (12.0%) patients developed persistent hypoparathyroidism in the first year follow\u2010up after surgery. Multivariable logistic regression analysis showed that \u0394PTH the day after surgery, corrected calcium the day after surgery, and not identifying at least one parathyroid during surgery were strong predictors for persistent hypoparathyroidism. The discriminative ability of the model was excellent (optimism\u2010corrected C\u2010index: 0.88, 95% CI: 0.84\u20130.92) with moderately calibrated predictions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The model proposed in this study could be used to perform an individual assessment of patients at risk for persistent hypoparathyroidism after total thyroidectomy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/coa.70039","type":"journal-article","created":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T11:46:08Z","timestamp":1759405568000},"page":"111-120","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Development and Validation of a Prognostic Model for Persistent Hypoparathyroidism After Total or Completion Thyroidectomy"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4745-7978","authenticated-orcid":false,"given":"Sam P. J.","family":"van Dijk","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology and Gastrointestinal Surgery Erasmus MC Cancer Institute  Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolien C. H. M.","family":"Maas","sequence":"additional","affiliation":[{"name":"Department of Public Health Erasmus University Medical Center  Rotterdam the Netherlands"},{"name":"Department of Research and Development Netherlands Comprehensive Cancer Organisation (IKNL)  Utrecht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Alshangi","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology and Gastrointestinal Surgery Erasmus MC Cancer Institute  Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. H. Elise","family":"van Driel","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology and Gastrointestinal Surgery Erasmus MC Cancer Institute  Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eline A.","family":"Feitsma","sequence":"additional","affiliation":[{"name":"Department of Surgery, University Medical Center Groningen University of Groningen  Groningen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline M. J.","family":"van Kinschot","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Erasmus Medical Center Rotterdam  Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivona","family":"Lon\u010dar","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology and Gastrointestinal Surgery Erasmus MC Cancer Institute  Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"van Noord","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Maasstad Hospital Rotterdam  Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linetta B.","family":"Koppert","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology and Gastrointestinal Surgery Erasmus MC Cancer Institute  Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Schelto","family":"Kruijff","sequence":"additional","affiliation":[{"name":"Department of Surgery, University Medical Center Groningen University of Groningen  Groningen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"van Klaveren","sequence":"additional","affiliation":[{"name":"Department of Public Health Erasmus University Medical Center  Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelis","family":"Verhoef","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology and Gastrointestinal Surgery Erasmus MC Cancer Institute  Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin P.","family":"Peeters","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Erasmus Medical Center Rotterdam  Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tessa M.","family":"van Ginhoven","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology and Gastrointestinal Surgery Erasmus MC Cancer Institute  Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"The Hypoparathyroidism Study Group of the Thyroid Network","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,2]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-019-02014-8"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.10843"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm4.10479"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/14574969221107282"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2016.08.019"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-20-0116"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2016.05.007"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.7326\/M14-0698"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje\u201021\u20101044"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v045.i03"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2006.01.009"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1996.10476908"},{"key":"e_1_2_12_14_1","unstructured":"F. E. H.Jr \u201crms: Regression Modeling Strategies. R Package Version 6.6\u20130 \u201dhttps:\/\/CRAN.R\u2010project.org\/package=rms."},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwu140"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-77244-8"},{"key":"e_1_2_12_17_1","unstructured":"C. C. H. M.Maas \u201cWeb Tool for Predicting Long\u2010Term Hypoparathyroidism \u201dhttps:\/\/erasmusmcpublichealth.shinyapps.io\/Hypoparathyroidism\/."},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1982.03320430047030"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-3462-1"},{"key":"e_1_2_12_20_1","unstructured":"Team RC \u201cR: A Language and Environment for Statistical Computing \u201dR Foundation for Statistical Computing Vienna Austria https:\/\/www.R\u2010project.org\/."},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.21037\/gs.2017.10.04"},{"issue":"5","key":"e_1_2_12_22_1","article-title":"High Incidence of Chronic Hypoparathyroidism Secondary to Total Thyroidectomy","volume":"67","author":"J\u00f8rgensen C. U.","year":"2020","journal-title":"Danish Medical Journal"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjsopen\/zrac102"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S157523"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.7992"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2015.04.005"}],"container-title":["Clinical Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/coa.70039","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T10:48:51Z","timestamp":1765795731000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/coa.70039"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,2]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/coa.70039"],"URL":"https:\/\/doi.org\/10.1111\/coa.70039","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/COA.70039\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.70039\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.70039\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.70039\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.70039\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.70039\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.70039\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.70039\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.70039\/v3\/decision1","asserted-by":"object"}]},"ISSN":["1749-4478","1749-4486"],"issn-type":[{"value":"1749-4478","type":"print"},{"value":"1749-4486","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,2]]},"assertion":[{"value":"2024-08-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}